Editorial: Understanding Molecular Mechanisms in Diabetic Cardiomyopathy (DCM)

Abstract

Cardiovascular disease is the leading cause of death worldwide, and diabetes, the most common metabolic syndrome, causes a 2–5 times higher risk for heart disease (1). Specifically, cardiovascular complications in people with diabetes mellitus (DM) are 2-3-fold more elevated than in non-diabetic counterparts, leading to a higher chance of causing diabetic cardiomyopathy (DCM). DCM is a prominent disease in people with DM, and molecular mechanisms that drive DCM are not fully understood as the disease itself is multifactorial and challenging potential treatment options (2). Therefore, this Research Topic is focused on understanding the molecular mechanism(s) contributing to DCM. The Research Topic comprised review and research articles from different experts working on DCM. The Research Topic of original research and review topics highlights the multifactorial molecular mechanisms involved in the DCM and some recent therapeutic advances in preclinical approaches at various levels in the pipeline.