Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome
![Thumbnail](/xmlui/bitstream/handle/10576/48448/ijms-23-09821-with-cover.pdf.jpg?sequence=4&isAllowed=y)
عرض / فتح
التاريخ
2022-08-29المؤلف
Mir, Fayaz AhmadUllah, Ehsan
Mall, Raghvendra
Iskandarani, Ahmad
Samra, Tareq A.
Cyprian, Farhan
Parray, Aijaz
Alkasem, Meis
Abdalhakam, Ibrahem
Farooq, Faisal
Abou-Samra, Abdul Badi
...show more authors ...show less authors
البيانات الوصفية
عرض كامل للتسجيلةالملخص
Background: Obesity coexists with variable features of metabolic syndrome, which is associated with dysregulated metabolic pathways. We assessed potential associations between serum metabolites and features of metabolic syndrome in Arabic subjects with obesity. Methods: We analyzed a dataset of 39 subjects with obesity only (OBO, n = 18) age-matched to subjects with obesity and metabolic syndrome (OBM, n = 21). We measured 1069 serum metabolites and correlated them to clinical features. Results: A total of 83 metabolites, mostly lipids, were significantly different (p < 0.05) between the two groups. Among lipids, 22 sphingomyelins were decreased in OBM compared to OBO. Among non-lipids, quinolinate, kynurenine, and tryptophan were also decreased in OBM compared to OBO. Sphingomyelin is negatively correlated with glucose, HbA1C, insulin, and triglycerides but positively correlated with HDL, LDL, and cholesterol. Differentially enriched pathways include lysine degradation, amino sugar and nucleotide sugar metabolism, arginine and proline metabolism, fructose and mannose metabolism, and galactose metabolism. Conclusions: Metabolites and pathways associated with chronic inflammation are differentially expressed in subjects with obesity and metabolic syndrome compared to subjects with obesity but without the clinical features of metabolic syndrome.
معرّف المصادر الموحد
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85137585363&origin=inwardالمجموعات
- أبحاث الطب [1418 items ]