E5 and E6/E7 of high-risk HPVs cooperate to enhance cancer progression through EMT initiation
| Author | Al Moustafa, Ala-Eddin |
| Available date | 2016-11-09T06:42:12Z |
| Publication Date | 2015-07-15 |
| Publication Name | Cell Adhesion & Migration |
| Identifier | http://dx.doi.org/10.1080/19336918.2015.1042197 |
| Citation | Ala-Eddin Al Moustafa (2015) E5 and E6/E7 of high-risk HPVs cooperate to enhance cancer progression through EMT initiation, Cell Adhesion & Migration, 9:5, 392-393 |
| ISSN | 1933-6918 |
| Abstract | It is estimated that 10–20% of human carcinogenesis is linked to virus infection including papillomaviruses (HPVs). Moreover, since metastatic cancer disease is a major cause of morbidity and mortality in cancer patients, the role of onco-viruses in cancer progression to a metastatic form is of particular interest. Recent studies reported that E5 and E6/E7 onco-proteins of high-risk HPVs could enhance cancer progression via the initiation of the epithelial–mesenchymal transition (EMT) event. Herein, we discuss the association between E5 as well as E6/E7 of high-risk HPV and cancer progression. |
| Sponsor | Canadian Institutes for Health Research, the Cancer Research Society Inc. of Canada, the National Colorectal Cancer Campaign and the Fonds de la Recherche en Sant e du Qu ebec (FRSQ- R eseau du Cancer |
| Language | en |
| Publisher | Taylor & Francis |
| Subject | high-risk HPV gene cooperation E6/E7 E5 cancer progression |
| Type | Article |
| Pagination | 392-393 |
| Issue Number | 5 |
| Volume Number | 9 |
| ESSN | 1933-6926 |
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