Biomedical Research Center: Recent submissions

Now showing items 1-20 of 880

    • Comparison of carbapenemase-producing Enterobacterales colonizing war-affected children from the Gaza Strip and hospitalized children from a national reference center in Qatar: an observational cohort study 

      Sharma, Anju; Sundararaju, Sathyavathi; Suleiman, Mohammed; Mohamed, Ruwa; Altrmanini, Diyna; ... more authors ( Elsevier , 2025 , Article)
      ObjectivesTo compare the rates and molecular characteristics of carbapenemase-producing Enterobacterales (CPE) from rectal screening swabs in war-affected Palestinian children in the Gaza Strip with those of the local ...

    • The role of small, dense lipoproteins in type-2 diabetes and maturity-onset diabetes of the young (MODY): What's new 

      Aleksandra, Zeljkovic; Vekic, Jelena; Elrayess, Mohamed A.; Rizzo, Manfredi ( Elsevier , 2025 , Article)
      Although diabetic dyslipidemia is a well-known and extensively studied phenomenon, its features continue to attract significant attention from both researchers and clinicians. Given that lipid profile abnormalities are ...

    • Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950–2023: a demographic analysis for the Global Burden of Disease Study 2023 

      Le, Minh Huu Nhat; Le, Thao Thi Thu; Ledda, Caterina; Lee, Wei-Chen; Lee, Ivan; ... more authors ( Elsevier , 2025 , Article)
      Comprehensive, comparable, and timely estimates of demographic metrics—including life expectancy and age-specific mortality—are essential for evaluating, understanding, and addressing trends in population health. The ...

    • Human Papillomavirus Vaccine Hesitancy among Teenage Girls in Nigeria: A Narrative Review 

      Ahmad, Dalhatu Muhammad; Catherine, Anozie Nneka; Christian, Nwankwo Emeka; Otsapa, Ajibo Thompson; Usman, Mustapha; ... more authors ( the Pharmaceutical Society of Nigeria (PSN) , 2025 , Article Review)
      Background: Despite the high prevalence of human papillomavirus (HPV) infections and cervicalcancer in Nigeria, the uptake of the HPV vaccine, a proven preventive measure against these conditions, remains limited. This ...

    • Role of Macrophages in Cardiac Remodeling: Cues From Zebrafish Heart. 

      Gaur, Himanshu; Hasan, Maram; Yalcin, Huseyin C ( Wiley , 2026 , Article Review)
      Macrophages are a key component of innate immunity and regulate cardiac phenotypes by their polarization state. The classical M1 macrophages are activated by pro-inflammatory stimuli, whereas M2 macrophages are activated ...

    • Dexamethasone chronotherapy of COVID-19 patients admitted to intensive care unit: an exploratory study 

      Abusamak, Mohammad O.; Ait Hssain, Ali; Chinta, Venkateswara Rao; Al-Waeli, Haider A.; Yassine, Hadi M.; ... more authors ( BioMed Central Ltd , 2025 , Article)
      Background: Dexamethasone has been demonstrated to be a potential treatment approach preventing COVID-19 related fatalities by managing the cytokine release storm (CRS). The expression of the inflammatory mediators involved ...

    • Health-related quality of life of adults with generalized pustular psoriasis in Malaysia: a cross-sectional study 

      Seah, Xin Qian; Ong, Siew Chin; Mohammed, Mustapha; Tay, Mei Ee; Selvarajah, Latha R.; ... more authors ( BioMed Central Ltd , 2025 , Article)
      Background: Generalized Pustular Psoriasis (GPP) is a rare but severe form of psoriasis, characterized by flares involving the sudden spread of erythema with sterile pustules, crusting, and scaling. Objective: The study ...

    • The role of immune checkpoints in modulating cancer stem cells anti-tumor immune responses: implications and perspectives in cancer therapy 

      Hussein, Ola Jihad; Rayan, Menatallah; Matarid, Tasnim R.; ElKhalifa, Dana H.; Abunada, Hanan H.; ... more authors ( BioMed Central Ltd , 2025 , Article Review)
      Cancer stem cells (CSCs) are a minor subpopulation of tumor cells characterized by self-renewal capacity and stemness features and are responsible for tumor progression and therapy resistance. Several studies have shown ...

    • One Health Antimicrobial Resistance in Qatar: A Comprehensive Systematic Review and Meta-Analysis of Animal, Food, and Environmental Reservoirs 

      Abu-Rub, Lubna I.; Kamar, Ristha; Fatin, Cut Salsabila; Zughaier, Susu M.; Eltai, Nahla O. ( MDPI , 2025 , Article)
      Background: Antimicrobial resistance (AMR) is a global threat that extends beyond clinical settings, impacting animals, food, and the environment. To the best of our knowledge, this review presents the first systematic ...

    • N-Lactoyl amino acids: insights from metabolite genome-wide association studies and phenome-wide association analysis 

      Elashi, Asma A.; Razzaq, Aleem; Anwardeen, Najeha; Naja, Khaled; Alshafai, Mashael; ... more authors ( Oxford University Press , 2025 , Article)
      N-lactoyl-amino acids (Lac-AA) are emerging as important metabolites with diverse physiological roles. This study integrates metabolomics and genomics to investigate the genetic determinants and clinical relevance of three ...

    • Economic burden and cost drivers of generalized pustular psoriasis: a systematic review 

      Seah, Xin Qian; Mohammed, Mustapha; Ong, Siew Chin ( Springer Nature , 2025 , Article)
      Generalized pustular psoriasis (GPP), as a rare type of life-threatening psoriasis with currently no effective treatment, imposes a huge economic burden on the healthcare systems. This systematic review aimed to summarize ...

    • In Vitro Analysis of the Dynamic Role of the Bacterial Virulence Factors in Skin Wound Healing 

      Hammad, Ayat S.; Zahedy, Sarah H.; Elqasass, Shatha S.; Said, Sawsan Sudqi; Elgamal, Abdelrahman M.; ... more authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)
      The skin acts as a primary barrier against environmental insults and maintains homeostasis. Injury initiates a wound healing cascade of hemostasis, inflammation, proliferation, and remodeling. In chronic wounds, persistent ...

    • Economic burden and cost drivers of interstitial lung disease: a systematic review 

      Chiew, Siow Yeh; Mohammed, Mustapha; Ong, Siew Chin ( Springer Science and Business Media Deutschland GmbH , 2025 , Article)
      Background: Interstitial lung disease (ILD) consists of many subtypes, with idiopathic pulmonary fibrosis (IPF) and subtypes that manifest as progressive pulmonary fibrosis (PPF) exhibit faster progression and poorer ...

    • Mental health of university students: a cross-sectional study from Qatar 

      Al-Jayyousi, Ghadir Fakhri; Shraim, Mujahed; O’Hara, Lily; Zolezzi, Monica; Al-Wattary, Noor; ... more authors ( Nature Research , 2025 , Article)
      This study explored the prevalence, associated factors, and management strategies related to mental health among university students in Qatar. A cross-sectional survey was conducted among students aged 18 and older. Data ...

    • Effectiveness and durability of a fourth dose of ancestral-strain mRNA vaccines against SARS-CoV-2 infection: a nationwide matched cohort study in Qatar 

      Sukik, Layan; Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; ... more authors ( Nature Research , 2025 , Article)
      Concerns about waning immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the emergence of new variants underscore the need for booster doses. Using a matched cohort design, this ...

    • Targeting CDKs in cancer therapy: advances in PROTACs and molecular glues 

      Marei, Hany E.; Bedair, Khaled; Hasan, Anwarul Ul; Al-Mansoori, Layla J.R.; Gaiba, Alice; ... more authors ( Nature Research , 2025 , Article Review)
      Essential transcription and cell cycle progression controllers are CDKs, whose dysregulation is a defining trait of many human cancers. CDKs have grown to be very crucial therapeutic targets in cancer. Although traditional ...

    • Meta-adaptive biomaterials: multiscale, spatiotemporal organization and actuation in engineered tissues 

      Cedillo-Servin, Gerardo; Al-Jehani, Essa A.A.; Rossy, Tamara; Teixeira, Simão P.B.; Sage, Fanny; ... more authors ( Elsevier , 2025 , Article)
      Organized cell architecture and dynamic forces are key for (re)creating native-like tissue function (e.g., contractile soft tissues). However, few studies have explored the combined effects of material-guided 3D cell ...

    • Serogroup W invasive meningococcal disease outbreak in Qatar following travel to Umrah 

      Ben Abid, Fatma; Ittaman, Ajithkumar Valooparambil; Ibrahim, Emad Basheir; Al-Wali, Walid; Hamed, Manal Mahmoud Mohamed; ... more authors ( Elsevier , 2025 , Article)
      Invasive meningococcal disease (IMD) is associated with significant morbidity and mortality in all age groups. Globally, reported cases predominantly belong to serogroups A, B, and C. Although serogroup W is less prevalent ...

    • Significance, clinical spectrum, and microbiological evaluation of Actinomyces blood stream infections 

      Ali, Maisa; Razok, Almurtada; Sasi, Sreethish; Balushi, Sara Al; Ibrahim, Emad B.; ... more authors ( Elsevier , 2025 , Article)
      ObjectivesActinomyces species are Gram-positive anaerobic bacilli that are commensal in the gastrointestinal and genital tracts. Actinomyces blood stream infections (BSIs) are rare but becoming more frequent with advanced ...

    • Estimating SARS-CoV-2 infection incidence and detection rates: Demonstrating a novel surveillance method 

      Ayoub, Houssein H.; Chemaitelly, Hiam; Tang, Patrick; Hasan, Mohammad R.; Yassine, Hadi M.; ... more authors ( Elsevier , 2025 , Article)
      ObjectivesAssessing the cumulative incidence of infection conventionally relies on documented infections or serological surveys, both of which have limitations. This study introduces a novel and practical method leveraging ...