Biomedical Research Center: Recent submissions
Now showing items 41-60 of 740
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Genomic characterization of plasmid-borne colistin resistance variants, mcr-1.1 and mcr-1.26, in multidrug-resistant Escherichia coli isolated from backyard farm animals
( Elsevier , 2024 , Article)Colistin remains a high-priority, critically important antimicrobial that is used for treating severe infections caused by multidrug-resistant (MDR) Gram-negative bacteria. However, colistin resistance and the emergence ... -
Chitin-based nanomaterials
( Elsevier , 2021 , Book chapter)Chitin- and chitosan-based materials have been increasingly used in various scientific advancements specifically in the field of nanotechnology for their therapeutic potential. They are biopolymeric polysaccharides with ... -
Identification of potential natural inhibitors of the receptor-binding domain of the SARS-CoV-2 spike protein using a computational docking approach
( HBKU Press , 2021 , Article)Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only zoonotic-origin CoV to reach the pandemic stage, to which neither an effective vaccine nor a specific therapy is available. The ... -
Characterizing the effective reproduction number during the COVID-19 pandemic: Insights from Qatar's experience
( Edinburgh University Global Health Society , 2022 , Article)Background The effective reproduction number, Rt, is a tool to track and understand pandemic dynamics. This investigation of Rt estimations was conducted to guide the national COVID-19 response in Qatar, from the onset of ... -
Smoking induced salivary microbiome dysbiosis and is correlated with lipid biomarkers
( Springer Nature , 2024 , Article)Background: The oral microbiome plays an essential role in maintaining oral homeostasis and health; smoking significantly affects it, leading to microbial dysbiosis. The study aims to investigate changes in the oral ... -
The tale of an endemic shrimp’s exceptional osmoregulation and the ancient Athalassic mangrove oasis
( Springer Nature , 2024 , Article)The hyperarid mangrove in the Middle East is characterised by the absence of rivers or freshwater inputs and is one of the most extreme settings of this ecosystem on Earth. Endemic to Qatar’s hyperarid mangroves, a Palaemon ... -
Role of genetics in eleven of the most common autoimmune diseases in the post genome-wide association studies era
( Verduci Editore s.r.l , 2023 , Article)Autoimmune diseases (ADs) are common conditions in which an individual’s immune system reacts against its healthy cells. This condition is a common cause of morbidity and mortality, with an estimated prevalence ranging ... -
Rapid Visual Detection of Methicillin-Resistant Staphylococcus aureus in Human Clinical Samples via Closed LAMP Assay Targeting mecA and spa Genes
( MDPI , 2024 , Article)The emergence of antimicrobial resistance (AMR), particularly methicillin-resistant Staphylococcus aureus (MRSA), poses a significant global health threat as these bacteria increasingly become resistant to the most available ... -
Antimicrobial Resistance in Qatar: Prevalence and Trends before and Amidst the COVID-19 Pandemic
( MDPI , 2024 , Article)Antimicrobial resistance (AMR) is a global healthcare challenge with substantial morbidity, mortality, and management costs. During the COVID-19 pandemic, there was a documented increase in antimicrobial consumption, ... -
In silico-designed antimicrobial peptide targeting MRSA and E. coli with antibacterial and antibiofilm actions
( Springer Nature , 2024 , Article)Antibiotic resistance is a paramount global health issue, with numerous bacterial strains continually fortifying their resistance against diverse antibiotics. This surge in resistance levels primarily stems from the overuse ... -
Novel Theileria sp. as an Etiology of Cutaneous Theileriosis among the Vulnerable Arabian Oryx
( MDPI , 2024 , Article)The Arabian Peninsula’s endemic ungulate, Oryx leucoryx, was on the verge of extinction at the end of the 1970s. Despite the different reintroduction programs, the International Union for Conservation of Nature is still ... -
Medicinal properties of Qatari wetland plants: A review
( AkiNik Publications , 2024 , Article)For over 60,000 years, human dependence on herbal remedies has been a cornerstone of traditional medicine. However, recent times have witnessed escalating concerns about the sustainability of these practices, especially ... -
Wastewater-based epidemiology for tracking bacterial diversity and antibiotic resistance in COVID-19 isolation hospitals in Qatar
( Elsevier , 2023 , Article)BackgroundHospitals are hotspots for antimicrobial resistance genes (ARGs), and play a significant role in their emergence and spread. Large numbers of ARGs will be ejected from hospitals via wastewater systems. Wastewater-based ... -
Whole genome-based genetic insights of bla NDM producing clinical E. coli isolates in hospital settings of Pakistant
( American Society for Microbiology , 2023 , Article)Carbapenem resistance among Enterobacterales has become a global health concern. Clinical Escherichia coli isolates producing the metallo β-lactamase NDM have been isolated from two hospitals in Faisalabad, Pakistan. These ... -
Granulomatous Mastitis With Breast Abscess Caused by Salmonella.
( Springer , 2023 , Report)Granulomatous mastitis (GM) is a rare disease that occurs in young premenopausal women, is mostly idiopathic, and is less likely to be caused by infection and trauma. It is also strongly associated with pregnancy, lactation, ... -
Antibacterial and catalytic performance of rGO-CNT-ZrO2 composite
( Taylor and Francis Group , 2023 , Article)In recent years, there has been a rise in public awareness regarding antibacterial properties and commercial opportunities for their use in the medical field. The current study describes the fabrication of a ternary ... -
Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential
( Elsevier , 2024 , Article)Plasticizers are considered as newly emerged contaminants. They are added to plastics to increase their flexibility and softness. Phthalate plasticizers including the Di-2-ethylhexyl phthalates (DEHP) are toxic and induce ... -
Detection of paracetamol as substrate of the gut microbiome
( Pakistan Journal of Pharmaceutical Sciences , 2019 , Article)Gut microbiome, a new organ; represent targets to alter pharmacokinetics of orally administered drugs. Recently, in vitro trials endorsed the idea that orally administered drugs interact and some of their quantity may be ... -
White button mushroom, agaricus bisporus (Agaricomycetes), and a probiotics mixture supplementation correct dyslipidemia without influencing the colon microbiome profile in hypercholesterolemic rats
( Begell House , 2020 , Article)Consumption of foods rich in dietary fiber has attracted considerable attention for lowering blood cholesterol and triglycerides through attenuation of gut microbiome. Diets rich in fiber may provide substrates for microbes ... -
Sulpiride Serves, a Substrate for the Gut Microbiome
( International Dose-Response Society , 2021 , Article)In the contemporary research world, the intestinal microbiome is now envisioned as a new body organ. Recently, the gut microbiome represents a new drug target in the gut, since various orthologues of intestinal drug ...
