• English
    • العربية
  • العربية
  • Login
  • QU
  • QU Library
  •  Home
  • Communities & Collections
  • Copyrights
View Item 
  •   Qatar University Digital Hub
  • Qatar University Institutional Repository
  • Academic
  • Faculty Contributions
  • College of Arts & Sciences
  • Mathematics, Statistics & Physics
  • View Item
  • Qatar University Digital Hub
  • Qatar University Institutional Repository
  • Academic
  • Faculty Contributions
  • College of Arts & Sciences
  • Mathematics, Statistics & Physics
  • View Item
  •      
  •  
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Comparative effectiveness of one versus two doses of COVID-19 vaccines in Qatar: Evidence of converging protection over time

    View/Open
    Publisher version (You have accessOpen AccessIcon)
    Publisher version (Check access options)
    Check access options
    1-s2.0-S0264410X25008539-main.pdf (2.324Mb)
    Date
    2025-08-30
    Author
    Hiam, Chemaitelly
    Ayoub, Houssein H.
    Coyle, Peter
    Tang, Patrick
    Hasan, Mohammad R.
    Yassine, Hadi M.
    Al Thani, Asmaa A.
    Al-Kanaani, Zaina
    Al-Kuwari, Einas
    Jeremijenko, Andrew
    Kaleeckal, Anvar Hassan
    Latif, Ali Nizar
    Shaik, Riyazuddin Mohammad
    Abdul-Rahim, Hanan F.
    Nasrallah, Gheyath K.
    Al-Kuwari, Mohamed Ghaith
    Butt, Adeel A.
    Al-Romaihi, Hamad Eid
    Al-Thani, Mohamed H.
    Al-Khal, Abdullatif
    Abu-Raddad, Laith J.
    ...show more authors ...show less authors
    Metadata
    Show full item record
    Abstract
    BackgroundSupply constraints during the coronavirus disease 2019 (COVID-19) pandemic led to vaccination strategies that prioritized first-dose coverage. To evaluate the merit of this approach, this study compared the development of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe COVID-19 following a single dose versus two doses across three widely used vaccine platforms. MethodsNational, matched, test-negative case-control analyses were conducted in Qatar between December 1, 2020, and December 18, 2021, to evaluate vaccine effectiveness. The one-dose analysis included 227,309 cases and 4,170,786 controls; the two-dose analysis included 234,314 cases and 6,445,858 controls. ResultsFor BNT162b2, single-dose effectiveness against infection increased steadily from 9.9 % (95 % CI: 6.7–13.0 %) in the first two weeks post-vaccination to 71.5 % (95 % CI: 45.5–85.1 %) by month 3, closely approaching the 74.5 % (95 % CI: 72.9–76.0 %) effectiveness observed after the two-dose primary series. Similar trends were observed for mRNA-1273 and ChAdOx1 nCoV-19, with mRNA-1273 reaching two-dose levels of effectiveness as early as month 2. In contrast to the gradual buildup of protection against infection, single-dose effectiveness against severe, critical, or fatal COVID-19 increased rapidly for all three vaccines, exceeding 85 % by day 21 and closely matching the protection achieved after two doses. ConclusionA single COVID-19 vaccine dose provides rapid, strong protection against severe outcomes, supporting first-dose prioritization during supply constraints. The slower development of protection against infection highlights the second dose's role in accelerating the immune response. Antigen dose appears to influence the speed of protection buildup.
    URI
    https://www.sciencedirect.com/science/article/pii/S0264410X25008539
    DOI/handle
    http://dx.doi.org/10.1016/j.vaccine.2025.127556
    http://hdl.handle.net/10576/66994
    Collections
    • Mathematics, Statistics & Physics [‎810‎ items ]

    entitlement


    Qatar University Digital Hub is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

    Contact Us
    Contact Us | QU

     

     

    Home

    Submit your QU affiliated work

    Browse

    All of Digital Hub
      Communities & Collections Publication Date Author Title Subject Type Language Publisher
    This Collection
      Publication Date Author Title Subject Type Language Publisher

    My Account

    Login

    Statistics

    View Usage Statistics

    Qatar University Digital Hub is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

    Contact Us
    Contact Us | QU

     

     

    Video