تصفح حسب المؤلف "Crovella, Sergio"
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25-Hydroxyvitamin D serum levels inversely correlate to disease severity and serum C-reactive protein levels in patients with hidradenitis suppurativa
Moltrasio, Chiara; Tricarico, Paola Maura; Genovese, Giovanni; Gratton, Rossella; Marzano, Angelo V.; Crovella, Sergio... more authors ... less authors ( Wiley , 2021 , Other)Vitamin D exerts functions in skin physiology by modulating keratinocyte proliferation and different immunoregulatory processes.1 In several dermatoses, vitamin D correlates to disease severity and is significantly lower ... -
Abrogation of ORF8-IRF3 binding interface with Carbon nanotube derivatives to rescue the host immune system against SARS-CoV-2 by using molecular screening and simulation approaches.
Suleman, Muhammad; Murshed, Abduh; Imran, Kashif; Khan, Abbas; Ali, Zafar; Albekairi, Norah A; Wei, Dong-Qing; Yassine, Hadi M; Crovella, Sergio... more authors ... less authors ( BMC , 2024 , Article)The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to over six million deaths worldwide. In human immune system, the type 1 interferon (IFN) pathway plays a crucial role in fighting viral infections. However, ... -
Advanced photodynamic therapy with an engineered M13 phage targeting EGFR: Mitochondrial localization and autophagy induction in ovarian cancer cell lines
Barbara, Bortot; Apollonio, Maura; Baj, Gabriele; Andolfi, Laura; Zupin, Luisa; Crovella, Sergio; di Giosia, Matteo; Cantelli, Andrea; Saporetti, Roberto; Ulfo, Luca; Petrosino, Annapaola; Di Lorenzo, Giovanni; Romano, Federico; Ricci, Giuseppe; Mongiat, Maurizio; Danielli, Alberto; Calvaresi, Matteo; Biffi, Stefania... more authors ... less authors ( Elsevier , 2022 , Article)Photodynamic therapy (PDT) is a potential synergistic approach to chemotherapy for treating ovarian cancer, the most lethal gynecologic malignancy. Here we used M13 bacteriophage as a targeted vector for the efficient ... -
Analysis of E2F1 single-nucleotide polymorphisms reveals deleterious non-synonymous substitutions that disrupt E2F1-RB protein interaction in cancer
Muhammad, Suleman; Khattak, Aishma; Akbar, Fazal; Rizwan, Muhammad; Tayyab, Muhammad; Yousaf, Muhammad; Khan, Abbas; Albekairi, Norah A.; Agouni, Abdelali; Crovella, Sergio... more authors ... less authors ( Elsevier , 2024 , Article)Cancer is a medical condition that is caused by the abnormal growth and division of cells, leading to the formation of tumors. The E2F1 and RB pathways are critical in regulating cell cycle, and their dysregulation can ... -
Aquaporins Are One of the Critical Factors in the Disruption of the Skin Barrier in Inflammatory Skin Diseases
Tricarico, Paola Maura; Mentino, Donatella; De Marco, Aurora; Del Vecchio, Cecilia; Garra, Sabino; Cazzato, Gerardo; Foti, Caterina; Crovella, Sergio; Calamita, Giuseppe... more authors ... less authors ( MDPI , 2022 , Article Review)The skin is the largest organ of the human body, serving as an effective mechanical barrier between the internal milieu and the external environment. The skin is widely considered the first-line defence of the body, with ... -
Autoinflammation in Syndromic Hidradenitis Suppurativa: The Role of AIM2.
Moltrasio, Chiara; Cagliani, Rachele; Sironi, Manuela; Clerici, Mario; Pontremoli, Chiara; Maronese, Carlo Alberto; Tricarico, Paola Maura; Crovella, Sergio; Marzano, Angelo Valerio... more authors ... less authors ( MDPI , 2023 , Report)AIM2 is a key cytoplasmatic pathogen-sensor that detects foreign DNA from viruses and bacteria; it can also recognize damaged or anomalous presence of DNA, promoting inflammasome assembly and activation with the secretion ... -
Bioactive Antimicrobial Peptides: A New Weapon to Counteract Zoonosis.
Zupin, Luisa; Santos-Silva, Carlos André Dos; Al Mughrbi, Aya R Hamad; Vilela, Livia Maria Batista; Benko-Iseppon, Ana Maria; Crovella, Sergio... more authors ... less authors ( MDPI , 2022 , Article Review)Zoonoses have recently become the center of attention of the general population and scientific community. Notably, more than 30 new human pathogens have been identified in the last 30 years, 75% of which can be classified ... -
Biological Pathways Associated With the Development of Pulmonary Toxicities in Mesothelioma Patients Treated With Radical Hemithoracic Radiation Therapy: A Preliminary Study.
Crovella, Sergio; Revelant, Alberto; Muraro, Elena; Moura, Ronald Rodrigues; Brandão, Lucas; Trovò, Marco; Steffan, Agostino; Zacchi, Paola; Zabucchi, Giuliano; Minatel, Emilio; Borelli, Violetta... more authors ... less authors ( Frontiers Media , 2021 , Article)Radical hemithoracic radiotherapy (RHR), after lung-sparing surgery, has recently become a concrete therapeutic option for malignant pleural mesothelioma (MPM), an asbestos-related, highly aggressive tumor with increasing ... -
Blue Laser Light Counteracts HSV-1 in the SH-SY5Y Neuronal Cell Model of Infection
Zupin, Luisa; Crovella, Sergio ( MDPI , 2022 , Other)Herpes simplex virus 1 (HSV-1) is wide-spread virus that triggers painful and recurrent infections, as herpes labialis, causing blister lesions on the lip. HSV-1 infection can be a lifelong condition starting from childhood ... -
Blue photobiomodulation LED therapy impacts SARS-CoV-2 by limiting its replication in Vero cells
Zupin, L.; Zupin, Luisa; Gratton, Rossella; Fontana, Francesco; Clemente, Libera; Pascolo, Lorella; Ruscio, Maurizio; Crovella, Sergio... more authors ... less authors ( Wiley , 2021 , Other)The study of any intervention able to counteract SARS-CoV-2 pandemic is considerably envisaged. It was previously shown, in in vitro models of infections, that the LED blue light is able to decrease the viral load of HSV-1 ... -
Brief Report: Polymorphisms in TNF-α/TNFR1 Pathway Genes Are Associated With CD4+ T-Cell Recovery in HIV-1–Infected Individuals on Antiretroviral Therapy
Celerino da Silva, Ronaldo; Alves, Neyla M. Pereira; Gondim Silva, Maria L.; Agrelli, Almerinda; Coelho, Antonio V. Campos; Guimarães, Rafael L.; Arraes, Luiz C.; Crovella, Sergio; Brandão, Lucas A. Cavalcanti... more authors ... less authors ( NLM (Medline) , 2021 , Article)Background: Antiretroviral therapy (ART) is an important hallmark of HIV-1 treatment, enabling viral load suppression to undetectable levels and CD4+ T-cell recovery. However, some individuals do not recover the CD4+ ... -
Can Polymorphisms in NLRP3 Inflammasome Complex Be Associated with Postmenopausal Osteoporosis Severity?
Guaraná, Werbson Lima; Lima, Camilla Albertina Dantas; Barbosa, Alexandre Domingues; Crovella, Sergio; Sandrin-Garcia, Paula ( MDPI , 2022 , Article)The immune system plays a critical role in bone homeostasis and, consequently, in the pathophysiology of postmenopausal osteoporosis (OP) since estrogen deficiency induces the inflammasome and increases production of ... -
CIITA gene polymorphism (rs3087456) in systemic lupus erythematosus and rheumatoid arthritis: A population-based cohort study
Lima, Suelen Cristina; Gomes da Silva, Isaura Isabelle Fonseca; Nascimento, Denise de Queiroga; de Moura, Ronald Rodrigues; Mesquita, Matheus da Silva; Asano, Nadja Maria Jorge; Fernandes, Gisele Vagjel; Valente, Lucila Maria; Rushansky, Eliezer; Mariano, Maria Helena Queiroz de Araújo; Xavier, Ricardo Machado; Chies, José Artur Bogo; Crovella, Sergio; Sandrin-Garcia, Paula... more authors ... less authors ( Wiley , 2021 , Other)Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are influenced by genetic variants in immune system HLA genes. The Class II Major Histocompatibility Complex Transactivator (CIITA) is an important co-activator ... -
Clinical and molecular characterization of hidradenitis suppurativa: a practical framework for novel therapeutic targets.
Moltrasio, Chiara; Tricarico, Paola Maura; Moura, Ronald; Brandao, Lucas André Cavalcanti; Crovella, Sergio; Marzano, Angelo Valerio... more authors ... less authors ( Karger Publishers , 2023 , Report)Background: The pathophysiological picture underlying hidradenitis suppurativa (HS) and its syndromic forms is still patchy, thus presenting a great challenge for dermatologists and researchers since just by better ... -
Clinical–Epidemiological Characteristics and IFITM-3 (rs12252) Variant Involvement in HIV-1 Mother-to-Children Transmission Susceptibility in a Brazilian Population
Leandro, Dalila Bernardes; Celerino da Silva, Ronaldo; Rodrigues, Jessyca Kalynne Farias; Leite, Maria Carollayne Gonçalves; Arraes, Luiz Claudio; Coelho, Antonio Victor Campos; Crovella, Sergio; Zupin, Luisa; Guimarães, Rafael Lima... more authors ... less authors ( MDPI , 2023 , Article)Mother-to-children transmission (MTCT) is the main infection route for HIV-1 in children, and may occur during pregnancy, delivery, and/or postpartum. It is a multifactorial phenomenon, where genetic variants play an ... -
Comparison between nucleic acid amplification tests, antigen immunofluorescence assay, and in vitro infectivity in SARS-CoV-2 diagnosis.
Zupin, Luisa; Fontana, Francesco; Clemente, Libera; Ruscio, Maurizio; Crovella, Sergio ( Springer , 2022 , Article)The number of SARS-CoV-2 detection tests requested to the laboratories has dramatically increased together with an urgent need to release reliable responses in a very short time. The two options taken into consideration ... -
Different molecular pathways are disrupted in Pyoderma gangrenosum patients and are associated with the severity of the disease.
Moura, Ronald Rodrigues; Brandão, Lucas; Moltrasio, Chiara; Agrelli, Almerinda; Tricarico, Paola Maura; Maronese, Carlo Alberto; Crovella, Sergio; Marzano, Angelo Valerio... more authors ... less authors ( Nature Research , 2023 , Article)Pyoderma gangrenosum (PG) is a rare inflammatory skin disease classified within the spectrum of neutrophilic dermatoses. The pathophysiology of PG is yet incompletely understood but a prominent role of genetics facilitating ... -
Differential distribution of vitamin D receptor (VDR) gene variants and its expression in systemic lupus erythematosus
De Azevêdo Silva, Jaqueline; de Lima, Suelen Cristina; Fragoso, Thiago Sotero; Cavalcanti, Catarina Addobbati Jordão; Barbosa, Alexandre Domingues; Borborema, Maria Eduarda de Albuquerque; de Lucena, Thays Maria Costa; Duarte, Angela Luzia Branco Pinto; Crovella, Sergio; Sandrin-Garcia, Paula... more authors ... less authors ( Wiley , 2022 , Article)Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder that displays an important genetic background. Vitamin D3 (VD3) through its receptor (VDR) plays an important immunomodulatory role in autoimmune ... -
Direct inactivation of SARS-CoV-2 by low level blue photobiomodulation LED at 470, 454 and 450 nm.
Zupin, Luisa; Gratton, Rossella; Milani, Margherita; Clemente, Libera; Fontana, Francesco; Ruscio, Maurizio; Crovella, Sergio... more authors ... less authors ( Wiley , 2022 , Article)Blue light has been already reported as able to counteract different types of microorganisms including Gram-positive and Gram-negative bacteria, fungi and viruses, especially the enveloped ones. It has been reported that ... -
Do inflammasome impact COVID-19 severity?
Calado, Maria Beatriz; da Silva Santana, Crislayne Emilly; Crovella, Sergio ( Springer , 2021 , Article Review)COVID-19 pandemic has proven to be a dramatic challenge, introducing huge clinical differences that demand extensive investigations. Severe and critical patients may present coagulopathies and microthrombi, which results ...