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المؤلفzakaria, zain z.
المؤلفbenslimane, fatiha m.
المؤلفnasrallah, gheyath k.
المؤلفshurbaji, samar
المؤلفyounes, nadin n.
المؤلفMraiche, Fatima
المؤلفDa’as, Sahar I.
المؤلفyalcin, huseyin c.
تاريخ الإتاحة2018-10-09T05:53:30Z
تاريخ النشر2018-09-27
اسم المنشورBioMed Research International
المعرّفhttp://dx.doi.org/10.1155/2018/1642684
الاقتباسZakaria, Z. Z., Benslimane, F. M., Nasrallah, G. K., Shurbaji, S., Younes, N. N., Mraiche, F., ... & Yalcin, H. C. (2018). Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity. BioMed Research International, 2018.
الرقم المعياري الدولي للكتاب2314-6133
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11132
الملخصOver the last decade, the zebrafish (Danio rerio) has emerged as amodel organismfor cardiovascular research.Zebrafish have several advantages over mammalian models. For instance, the experimental cost of using zebrafish is comparatively low; the embryos are transparent, develop externally, and have high fecundity making them suitable for large-scale genetic screening. More recently, zebrafish embryos have been used for the screening of a variety of toxic agents, particularly for cardiotoxicity testing. Zebrafish has been shown to exhibit physiological responses that are similar to mammals after exposure to medicinal drugs including xenobiotics, hormones, cancer drugs, and also environmental pollutants, including pesticides and heavy metals. In this review, we provided a summary for recent studies that have used zebrafish to investigate themolecularmechanisms of drug-induced cardiotoxicity. More specifically, we focused on the techniques that were exploited by us and others for cardiovascular toxicity assessment and described several microscopic imaging and analysis protocols that are being used for the estimation of a variety of cardiac hemodynamic parameters.
راعي المشروعHuseyin C. Yalcin is supported by Qatar National Research Fund (QNRF), National Priority Research Program NPRP 10-0123-170222,and Qatar University internal funds,QUUGBRC-2017-3 and QUST-BRC-SPR\2017-1. The publication of this article was partially funded by the Qatar National Library.
اللغةen
الناشرHindawi Publishing Corporation
الموضوعzebrafish
microscopy
hemodynamics
teratogenicity
heart function
blood flow
cardiotoxicity
العنوانUsing Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity
النوعArticle
الصفحات1-10
رقم المجلد2018
ESSN2314-6141
dc.accessType Open Access


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