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المؤلفDas, Sandra Concepcion
المؤلفAl-Naemi, Hamda A.
تاريخ الإتاحة2020-09-14T06:52:38Z
تاريخ النشر2019
اسم المنشورOccupational Diseases and Environmental Medicine
المعرّفhttp://dx.doi.org/10.4236/odem.2019.74012
الاقتباسDas, S. and Al-Naemi, H. (2019) Cadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury. Occupational Diseases and Environmental Medicine, 7, 144-163. doi: 10.4236/odem.2019.74012.
الرقم المعياري الدولي للكتاب2333-3561
معرّف المصادر الموحدhttp://hdl.handle.net/10576/16095
الملخصCadmium is a known environmental pollutant targeting various organs. Often implicated in cadmium toxicology is the formation of reactive oxygen species, overwhelming the free radical scavenging mechanisms and inducing oxidative stress. Acute cadmium intoxication has been shown to reduce antioxidant enzyme activity and induce oxidative stress. However, chronic intoxication has obscure outcomes in oxidative stress while the cell makes adjustments to overcome the toxicant load. Also linked with the occurrence of oxidative stress is inflammation. Stimulation of acute or chronic inflammation is mediated by different cascades. However, key events include activation of transcription factor, NF-κB and release of pro-inflammatory cytokines. Both oxidative stress and inflammation are implicated simultaneously in pathogenesis and induction of multi-organ tissue damage under cadmium exposure. This article reviews the impact of acute and chronic cadmium intoxication on inducing oxidative stress, inflammation and thereby inflicting tissue damage
اللغةen
الناشرScientific Research Publishing
الموضوعCadmium
Inflammation
Tissue Injury
العنوانCadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury
النوعArticle Review
الصفحات144-163
رقم المجلد7
ESSN2333-357X
dc.accessType Open Access


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