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AuthorDas, Sandra Concepcion
AuthorAl-Naemi, Hamda A.
Available date2020-09-14T06:52:38Z
Publication Date2019
Publication NameOccupational Diseases and Environmental Medicineen_US
Identifierhttp://dx.doi.org/10.4236/odem.2019.74012
CitationDas, S. and Al-Naemi, H. (2019) Cadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury. Occupational Diseases and Environmental Medicine, 7, 144-163. doi: 10.4236/odem.2019.74012.
ISSN2333-3561
URIhttp://hdl.handle.net/10576/16095
AbstractCadmium is a known environmental pollutant targeting various organs. Often implicated in cadmium toxicology is the formation of reactive oxygen species, overwhelming the free radical scavenging mechanisms and inducing oxidative stress. Acute cadmium intoxication has been shown to reduce antioxidant enzyme activity and induce oxidative stress. However, chronic intoxication has obscure outcomes in oxidative stress while the cell makes adjustments to overcome the toxicant load. Also linked with the occurrence of oxidative stress is inflammation. Stimulation of acute or chronic inflammation is mediated by different cascades. However, key events include activation of transcription factor, NF-κB and release of pro-inflammatory cytokines. Both oxidative stress and inflammation are implicated simultaneously in pathogenesis and induction of multi-organ tissue damage under cadmium exposure. This article reviews the impact of acute and chronic cadmium intoxication on inducing oxidative stress, inflammation and thereby inflicting tissue damage
Languageen
PublisherScientific Research Publishing
SubjectCadmium
SubjectInflammation
SubjectTissue Injury
TitleCadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury
TypeArticle Review
Pagination144-163
Volume Number7
ESSN2333-357X


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