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    mRNA-1273 COVID-19 vaccine effectiveness against the B.1.1.7 and B.1.351 variants and severe COVID-19 disease in Qatar

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    Date
    2021-09-01
    Author
    Chemaitelly, Hiam
    Yassine, Hadi M.
    Benslimane, Fatiha M.
    Al Khatib, Hebah A.
    Tang, Patrick
    Hasan, Mohammad R.
    Malek, Joel A.
    Coyle, Peter
    Ayoub, Houssein H.
    Al Kanaani, Zaina
    Al Kuwari, Einas
    Jeremijenko, Andrew
    Kaleeckal, Anvar Hassan
    Latif, Ali Nizar
    Shaik, Riyazuddin Mohammad
    Abdul Rahim, Hanan F.
    Nasrallah, Gheyath K.
    Al Kuwari, Mohamed Ghaith
    Al Romaihi, Hamad Eid
    Al-Thani, Mohamed H.
    Al Khal, Abdullatif
    Butt, Adeel A.
    Bertollini, Roberto
    Abu-Raddad, Laith J.
    ...show more authors ...show less authors
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    Abstract
    The SARS-CoV-2 pandemic continues to be a global health concern. The mRNA-1273 (Moderna) vaccine was reported to have an efficacy of 94.1% at preventing symptomatic COVID-19 due to infection with ‘wild-type’ variants in a randomized clinical trial. Here, we assess the real-world effectiveness of this vaccine against SARS-CoV-2 variants of concern, specifically B.1.1.7 (Alpha) and B.1.351 (Beta), in Qatar, a population that comprises mainly working-age adults, using a matched test-negative, case-control study design. We show that vaccine effectiveness was negligible for 2 weeks after the first dose, but increased rapidly in the third and fourth weeks immediately before administration of a second dose. Effectiveness against B.1.1.7 infection was 88.1% (95% confidence interval (CI): 83.7–91.5%) ≥14 days after the first dose but before the second dose, and was 100% (95% CI: 91.8–100.0%) ≥14 days after the second dose. Analogous effectiveness against B.1.351 infection was 61.3% after the first dose (95% CI: 56.5–65.5%) and 96.4% after the second dose (95% CI: 91.9–98.7%). Effectiveness against any severe, critical or fatal COVID-19 disease due to any SARS-CoV-2 infection (predominantly B.1.1.7 and B.1.351) was 81.6% (95% CI: 71.0–88.8%) and 95.7% (95% CI: 73.4–99.9%) after the first and second dose, respectively. The mRNA-1273 vaccine is highly effective against B.1.1.7 and B.1.351 infections, whether symptomatic or asymptomatic, and against any COVID-19 hospitalization and death, even after a single dose.
    URI
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85110038106&origin=inward
    DOI/handle
    http://dx.doi.org/10.1038/s41591-021-01446-y
    http://hdl.handle.net/10576/24582
    Collections
    • Biomedical Research Center Research [‎786‎ items ]
    • Biomedical Sciences [‎802‎ items ]
    • COVID-19 Research [‎848‎ items ]
    • Mathematics, Statistics & Physics [‎786‎ items ]
    • Public Health [‎484‎ items ]

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