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المؤلفShaito, Abdullah
المؤلفAramouni, Karl
المؤلفAssaf, Roland
المؤلفParenti, Astrid
المؤلفOrekhov, Alexander
المؤلفEl Yazbi, Ahmed
المؤلفPintus, Gianfranco
المؤلفEid, Ali H.
تاريخ الإتاحة2022-03-23T05:16:02Z
تاريخ النشر2022
اسم المنشورFrontiers in Bioscience-Landmark
المعرّفhttp://dx.doi.org/10.31083/j.fbl2703105
الاقتباسAbdullah Shaito, Karl Aramouni, Roland Assaf, Astrid Parenti, Alexander Orekhov, Ahmed El Yazbi, Gianfranco Pintus, Ali H. Eid. Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases. Front. Biosci. (Landmark Ed) 2022, 27(3), 105. https://doi.org/10.31083/j.fbl2703105
الرقم المعياري الدولي للكتاب2768-6701
معرّف المصادر الموحدhttp://hdl.handle.net/10576/28498
الملخصCardiovascular disease (CVD) is a major cause of mortality worldwide. A better understanding of the mechanisms underlying CVD is key for better management or prevention. Oxidative stress has been strongly implicated in the pathogenesis of CVD. Indeed, several studies demonstrated that reactive oxygen species (ROS), via different mechanisms, can lead to endothelial cell (EC) dysfunction, a major player in the etiology of several CVDs. ROS appears to modulate a plethora of EC biological processes that are critical for the integrity of the endothelial function. This review seeks to dissect the role of oxidative stress-induced endothelial dysfunction in CVD development, with emphasis on the underlying mechanisms and pathways. Special attention is given to ROS-induced reduction of NO bioavailability, ROS-induced inflammation, and ROS-induced mitochondrial dysfunction. A better understanding and appraisal of these pathways may be essential to attenuate oxidative stress or reverse EC dysfunction, and hence, reduce CVD burden.
راعي المشروعThis work has been made possible thanks to grants from the University of Sharjah (Seed 2001050151, collaborative 2101050160), fondo UNISS di Ateneo per la Ricerca 2020.
اللغةen
الناشرIMR Press
الموضوعendothelial cell dysfunction
oxidative stress
reactive oxygen species (ROS)
cardiovascular diseases (CVDs)
nitric oxide
eNOS uncoupling
inflammation
mitochondrial dysfunction
العنوانOxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases
النوعArticle Review
رقم العدد3
رقم المجلد27
ESSN2768-6698
dc.accessType Open Access


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