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AuthorShaito, Abdullah
AuthorAramouni, Karl
AuthorAssaf, Roland
AuthorParenti, Astrid
AuthorOrekhov, Alexander
AuthorEl Yazbi, Ahmed
AuthorPintus, Gianfranco
AuthorEid, Ali H.
Available date2022-03-23T05:16:02Z
Publication Date2022
Publication NameFrontiers in Bioscience-Landmark
Identifierhttp://dx.doi.org/10.31083/j.fbl2703105
CitationAbdullah Shaito, Karl Aramouni, Roland Assaf, Astrid Parenti, Alexander Orekhov, Ahmed El Yazbi, Gianfranco Pintus, Ali H. Eid. Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases. Front. Biosci. (Landmark Ed) 2022, 27(3), 105. https://doi.org/10.31083/j.fbl2703105
ISSN2768-6701
URIhttp://hdl.handle.net/10576/28498
AbstractCardiovascular disease (CVD) is a major cause of mortality worldwide. A better understanding of the mechanisms underlying CVD is key for better management or prevention. Oxidative stress has been strongly implicated in the pathogenesis of CVD. Indeed, several studies demonstrated that reactive oxygen species (ROS), via different mechanisms, can lead to endothelial cell (EC) dysfunction, a major player in the etiology of several CVDs. ROS appears to modulate a plethora of EC biological processes that are critical for the integrity of the endothelial function. This review seeks to dissect the role of oxidative stress-induced endothelial dysfunction in CVD development, with emphasis on the underlying mechanisms and pathways. Special attention is given to ROS-induced reduction of NO bioavailability, ROS-induced inflammation, and ROS-induced mitochondrial dysfunction. A better understanding and appraisal of these pathways may be essential to attenuate oxidative stress or reverse EC dysfunction, and hence, reduce CVD burden.
SponsorThis work has been made possible thanks to grants from the University of Sharjah (Seed 2001050151, collaborative 2101050160), fondo UNISS di Ateneo per la Ricerca 2020.
Languageen
PublisherIMR Press
Subjectendothelial cell dysfunction
oxidative stress
reactive oxygen species (ROS)
cardiovascular diseases (CVDs)
nitric oxide
eNOS uncoupling
inflammation
mitochondrial dysfunction
TitleOxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases
TypeArticle Review
Issue Number3
Volume Number27
ESSN2768-6698
dc.accessType Open Access


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