Browsing Medicine Research by Author "Sahebkar, Amirhossein"

Now showing items 1-20 of 22

    • Biochemical and cellular basis of oxidative stress: Implications for disease onset 

      Aramouni, Karl; Assaf, Roland; Shaito, Abdullah; Fardoun, Manal; Al-Asmakh, Maha; ... more authors ( Wiley , 2023 , Article Review)
      Cellular oxidation–reduction (redox) systems, which encompass pro- and antioxidant molecules, are integral components of a plethora of essential cellular processes. Any dysregulation of these systems can cause molecular ...

    • Bridging conventional medicine and traditional, complementary, and alternative approaches: Fostering collaborative attempts for a holistic healthcare system 

      Eid, Ali H.; Sahebkar, Amirhossein ( Elsevier , 2023 , Other)
      Dear Editor, We read the paper entitled “The future of integrative health: vision, values, and principles for positive, sustainable systemic change” by Kemper, which was published last month.1 The points discussed therein ...

    • C-peptide in diabetes: A player in a dual hormone disorder? 

      Dakroub, Ali; Dbouk, Ali; Asfour, Aref; Nasser, Suzanne A.; El-Yazbi, Ahmed F.; ... more authors ( Wiley-Blackwell , 2024 , Article)
      C-peptide, a byproduct of insulin synthesis believed to be biologically inert, is emerging as a multifunctional molecule. C-peptide serves an anti-inflammatory and anti-atherogenic role in type 1 diabetes mellitus (T1DM) ...

    • Cardioprotective Effect of Rheum turkestanicum Against Doxorubicin-Induced Toxicity in Rats 

      Hosseini, Azar; Safari, Mohammad Kazem; Rajabian, Arezoo; Boroumand-Noughabi, Samaneh; Eid, Ali H.; ... more authors ( Frontiers Media S.A. , 2022 , Article)
      Background: Doxorubicin as an anti-cancer drug causes cardiotoxicity, limiting its tolerability and use. The mechanism of toxicity is due to free radical production and cardiomyocytes injury. This research evaluated Rheum ...

    • Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats 

      Hosseini, Azar; Ghorbani, Atieh; Alavi, Mohaddeseh Sadat; Forouhi, Nima; Rajabian, Arezoo; ... more authors ( Frontiers Media SA , 2023 , Article)
      Introduction: Oxidative stress is a major instigator of various cardiovascular diseases, including myocardial infarction (MI). Despite available drugs, there is still an increased need to look for alternative therapies or ...

    • Diagnostic Value of Non-invasive Liver Function Tests in Liver Fibrosis and Changes in These Parameters Post-metabolic Surgery 

      Jangjoo, Sara; Emami, Nima; Sahranavard, Mehrdad; Shah, Najeeb Z.; Alidadi, Mona; ... more authors ( Springer , 2023 , Article)
      Purpose: This study aimed to ascertain the diagnostic accuracy of non-invasive liver function tests in liver fibrosis and assess their changes after metabolic surgery. Materials and Methods: 1005 individuals with severe ...

    • Effect of Bariatric Surgery on Serum Amyloid A Protein: a Systematic Review and Meta-analysis 

      Jamialahamdi, Tannaz; Mirhadi, Elaheh; Atkin, Stephen L.; le Roux, Carel W.; Kroh, Matthew; ... more authors ( springer link , 2023 , Article)
      Background: Obesity is a chronic inflammatory condition and this meta-analysis evaluated the impact of bariatric surgery on SAA. Methods: Studies included all types of bariatric surgery where SAA was measured before and ...

    • The effect of nuts consumption on circulating oxidized low-density lipoproteins: A systematic review and meta-analysis of randomized controlled trials. 

      Abbasifard, Mitra; Jamialahmadi, Tannaz; Reiner, Željko; Eid, Ali H; Sahebkar, Amirhossein ( Wiley , 2023 , Article Review)
      This systematic review and meta-analysis evaluated the effect of nuts in decreasing circulating levels of oxidized low-density lipoproteins (ox-LDL). A literature search was performed of major electronic databases ...

    • Effect of statins on abdominal aortic aneurysm 

      Azar, Hosseini; Sahranavard, Toktam; Reiner, Željko; Jamialahmadi, Tannaz; Dhaheri, Yusra Al; ... more authors ( Elsevier , 2022 , Article Review)
      Abdominal aortic aneurysm (AAA) is a prevalent condition which causes progressive growth and rupture of aortic wall with a high death rate. Several studies have found that treatment with statins may decrease the progress ...

    • The Effects of Statin Treatment on Serum Ferritin Levels: A Systematic Review and Meta-Analysis 

      Jamialahmadi, Tannaz; Abbasifard, Mitra; Reiner, Željko; Rizzo, Manfredi; Eid, Ali H.; ... more authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)
      Background: Statins are the most widely used drugs for decreasing elevated serum LDL-cholesterol (LDL-C) and thus for the prevention of atherosclerotic cardiovascular disease (ASCVD), but they have also some pleiotropic ...

    • Effects of Trehalose Administration in Patients with Mucopolysaccharidosis Type III. 

      Mobini, Moein; Radbakhsh, Shabnam; Kubaski, Francyne; Eshraghi, Peyman; Vakili, Saba; ... more authors ( Europe PMC , 2023 , Article)
      Mucopolysaccharidosis type III (MPS III) is a rare autosomal recessive lysosomal storage disease (LSD) caused by a deficiency of lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs), mainly in the ...

    • Five insights from the Global Burden of Disease Study 2019 

      Christopher J L, Murray; Abbafati, Cristiana; Abbas, Kaja M; Abbasi, Mohammad; Abbasi-Kangevari, Mohsen; ... more authors ( Elsevier , 2020 , Article Review)
      The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system ...

    • Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019 

      Haidong, Wang; Abbas, Kaja M; Abbasifard, Mitra; Abbasi-Kangevari, Mohsen; Abbastabar, Hedayat; ... more authors ( Elsevier , 2020 , Article)
      BackgroundAccurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, ...

    • Global Burden of Cardiovascular Diseases and Risks, 1990-2022 

      George A., Mensah; Fuster, Valentin; Murray, Christopher J.L.; Roth, Gregory A.; Mensah, George A.; ... more authors ( Elsevier , 2023 , Other)
      The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) is a multinational collaborative research study with >10,000 collaborators around the world. GBD generates a time series of summary measures of health, ...

    • Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021 

      Natalia V, Bhattacharjee; Schumacher, Austin E; Aali, Amirali; Abate, Yohannes Habtegiorgis; Abbasgholizadeh, Rouzbeh; ... more authors ( Elsevier , 2024 , Article)
      BackgroundAccurate assessments of current and future fertility—including overall trends and changing population age structures across countries and regions—are essential to help plan for the profound social, economic, ...

    • Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 

      Rafael, Lozano; Fullman, Nancy; Mumford, John Everett; Knight, Megan; Barthelemy, Celine M; ... more authors ( Elsevier , 2020 , Article)
      BackgroundAchieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority ...

    • MicroRNA-mediated regulation of LDL receptor: biological and pharmacological implications. 

      Keshavarz, Reyhaneh; Reiner, Željko; Zengin, Gokhan; Eid, Ali H; Sahebkar, Amirhossein ( Europe PM , 2023 , Article)
      One of the main causes of atherosclerosis is a disruption in cellular cholesterol hemostasis. The low-density lipoprotein receptor (LDLR) is an important factor in maintaining cholesterol homeostasis by the receptor-mediated ...

    • Paradoxical effects of statins on endothelial and cancer cells: the impact of concentrations 

      Ahmadi, Yasin; Fard, Javad Khalili; Ghafoor, Dlzar; Eid, Ali H.; Sahebkar, Amirhossein ( Springer Nature , 2023 , Article)
      In addition to their lipid-lowering functions, statins elicit additional pleiotropic effects on apoptosis, angiogenesis, inflammation, senescence, and oxidative stress. Many of these effects have been reported in cancerous ...

    • The pharmaco-epigenetics of hypertension: a focus on microRNA 

      Yaacoub, Serge; Boudaka, Ammar; AlKhatib, Ali; Pintus, Gianfranco; Sahebkar, Amirhossein; ... more authors ( Springer Nature , 2024 , Article)
      Hypertension is a major harbinger of cardiovascular morbidity and mortality. It predisposes to higher rates of myocardial infarction, chronic kidney failure, stroke, and heart failure than most other risk factors. By 2025, ...

    • Pleiotropic properties of statins via angiogenesis modulation in cardiovascular disease 

      Fatemeh, Zahedipour; Butler, Alexandra E.; Eid, Ali H.; Sahebkar, Amirhossein ( Elsevier , 2022 , Article)
      Inhibition of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase by statins is affected by inhibiting the active site of the enzyme in a competitive manner. Statins reduce plasma cholesterol by inhibiting its de novo ...