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السجلات المعروضة 845 -- 864 من 1418
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Metabolic-associated fatty liver disease: a selective review of pathogenesis, diagnostic approaches, and therapeutic strategies.
( Frontiers Media , 2024 , Article Review)Metabolic associated fatty liver disease (MAFLD) is a novel terminology introduced in 2020 to provide a more accurate description of fatty liver disease associated with metabolic dysfunction. It replaces the outdated term ... -
Metabolomic profiling reveals key metabolites associated with hypertension progression
( Frontiers Media SA , 2024 , Article)Introduction: Pre-hypertension is a prevalent condition among the adult population worldwide. It is characterized by asymptomatic elevations in blood pressure beyond normal levels but not yet reaching the threshold for ... -
Metabolomics Profiling of Stages of Coronary Artery Disease Progression
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Coronary artery disease (CAD) and atherosclerosis pose significant global health challenges, with intricate molecular changes influencing disease progression. Hypercholesterolemia (HC), hypertension (HT), and diabetes are ... -
Metabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia
( MDPI , 2022 , Article)Vitamin D deficiency is a global disorder associated with several chronic illnesses including dyslipidemia and metabolic syndrome. The impact of this association with both dyslipidemia and vitamin D deficiency on metabolomics ... -
Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases
( Elsevier , 2021 , Article)Cardiovascular disease (CVD) is the leading cause of death worldwide. A search for more effective treatments of CVD is increasingly needed. Major advances in nanotechnology opened new avenues in CVD therapeutics. Owing to ... -
Metformin in pregnancy to avert gestational diabetes in women at high risk: Meta-analysis of randomized controlled trials.
( Wiley , 2019 , Article Review)Previous randomized and observational studies on the efficacy of metformin in pregnancy to reduce incident gestational diabetes mellitus (GDM) in women at high risk (obesity, polycystic ovary syndrome [PCOS], or pregestational ... -
Metformin is comparable to insulin for pharmacotherapy in gestational diabetes mellitus: A network meta-analysis evaluating 6046 women.
( Elsevier , 2021 , Article)The comparative efficacy of gestational diabetes (GDM) treatments lack conclusive evidence for choice of first-line treatment. The aim of this study was to compare the efficacy of metformin and glibenclamide to insulin ... -
Methodological assessment of systematic reviews and meta-analyses on COVID-19: A meta-epidemiological study
( Wiley , 2021 , Article)Rationale, aims, and objectives: COVID-19 has caused an ongoing public health crisis. Many systematic reviews and meta-analyses have been performed to synthesize evidence for better understanding this new disease. However, ... -
Methodological considerations for identifying multiple plasma proteins associated with all-cause mortality in a population-based prospective cohort
( Nature Research , 2021 , Article)Novel methods to characterize the plasma proteome has made it possible to examine a wide range of proteins in large longitudinal cohort studies, but the complexity of the human proteome makes it difficult to identify robust ... -
Methodological issues of systematic reviews and meta-analyses in the field of sleep medicine: A meta-epidemiological study
( Elsevier , 2021 , Article)An increasing number of systematic reviews and meta-analyses (SRMAs) have been published in the field of sleep medicine. We evaluated the methodological issues of these SRMAs. A protocol was developed in advance. Three ... -
Methodological quality assessment should move beyond design specificity.
( Lippincott, Williams & Wilkins , 2023 , Article)This study aimed to assess the utility of a unified tool (MASTER) for bias assessment against design-specific tools in terms of content and coverage. Each of the safeguards in the design-specific tools was compared and ... -
Methodological quality for systematic reviews of adverse events with surgical interventions: a cross-sectional survey.
( BMC , 2021 , Article)An increasing number of systematic reviews assessed the safety of surgical interventions over time. How well these systematic reviews were designed and conducted determines the reliability of evidence. In this study, we ... -
The MethodologicAl STandards for Epidemiological Research (MASTER) scale demonstrated a unified framework for bias assessment
( Elsevier , 2021 , Article)Objective: This paper presents a unified framework for assessment of the methodological quality of analytic study designs. Study Design and Setting: A systematic review of 393 methodological quality assessment tools that ... -
Methylglyoxal and glyoxalase 1-a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes
( Portland Press Ltd , 2022 , Article)The study of the glyoxalase system by Thornalley and co-workers in clinical diabetes mellitus and correlation with diabetic complications revealed increased exposure of patients with diabetes to the reactive, dicarbonyl ... -
Metronidazole in conjunction with penicillin neither prevents recurrence nor enhances recovery from peritonsillar abscess when compared with penicillin alone: A prospective, double-blind, randomized, placebo-controlled trial
( Oxford University Press , 2016 , Article)Objectives The objectives of this study were to evaluate the efficacy of metronidazole in conjunction with penicillin in preventing the recurrence of peritonsillar abscess (PTA) and to learn whether metronidazole enhances ... -
Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity
( Elsevier Ltd , 2019 , Article)The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally ... -
Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity
( Elsevier , 2019 , Article)The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally ... -
Microneedles: A new generation vaccine delivery system
( MDPI , 2021 , Article Review)Transdermal vaccination route using biodegradable microneedles is a rapidly progressing field of research and applications. The fear of painful needles is one of the primary reasons most people avoid getting vaccinated. ... -
MicroRNA-mediated regulation of LDL receptor: biological and pharmacological implications.
( Europe PM , 2023 , Article)One of the main causes of atherosclerosis is a disruption in cellular cholesterol hemostasis. The low-density lipoprotein receptor (LDLR) is an important factor in maintaining cholesterol homeostasis by the receptor-mediated ... -
Mitigating Cardiotoxicity of Dendrimers: Angiotensin-(1-7) via Its Mas Receptor Ameliorates PAMAM-Induced Cardiac Dysfunction in the Isolated Mammalian Heart
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Aim: The influence of the physiochemical properties of dendrimer nanoparticles on cardiac contractility and hemodynamics are not known. Herein, we investigated (a) the effect of polyamidoamine (PAMAM) dendrimer generation ...