Browsing Medicine Research by Title
Now showing items 876-895 of 1337
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New insight into the role of PTCH1 protein in serous ovarian carcinomas.
( Spandidos Publications , 2022 , Article)The Hedgehog (Hh) signaling pathway is essential for normal embryonic development, while its hyperactivation in the adult organism is associated with the development of various cancers. The role of the Hh signaling pathway ... -
A new method for synthesizing test accuracy data outperformed the bivariate method
( Elsevier , 2020 , Article)This paper outlines the development of a new method (split component synthesis; SCS) for meta-analysis of diagnostic accuracy studies and assesses its performance against the commonly used bivariate random effects model. ... -
Nicolau syndrome following Intramuscular Diclofenac Injection: a case report and review of the literature.
( Oxford University Press , 2023 , Article)Nicolau syndrome (NS), also referred as embolia cutis medicamentosa and livedo-like dermatitis, is an uncommon complication followed by drugs administered intramuscularly, intraarticularly or subcutaneously. In this case ... -
No Association Between Ct Value and COVID-19 Severity and Mortality in Qatar.
( Dove Press Ltd , 2023 , Article)The association between the cycle threshold (Ct) which reflects the SARS-CoV-2 viral load and the severity of COVID-19 is still not clear. We investigated the association between Ct values, symptoms and the risk of ICU ... -
Nociceptor subtypes and their incidence in rat lumbar dorsal root ganglia (DRGs): focussing on C-polymodal nociceptors, A?-nociceptors, moderate pressure receptors and their receptive field depths
( Elsevier Ltd , 2019 , Article Review)A recent study with Ca++-sensitive-dyes in neurons in whole DRGs (Table 5) found that much lower percentages of nociceptors were polymodal-nociceptors (PMNs) (Emery et al., 2016), than the 50–80% values in many ... -
The Non-Coding RNA and Its Role in Tumor Therapy-Induced Resistance.
( MDPI , 2020 , Article)The growth arrest-specific transcript 5 () is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, ... -
Non-ST-Segment Elevation Myocardial Infarction Shortly After Starting Steroid Replacement Therapy in a Patient With Adrenal Insufficiency.
(2022 , Article)Adrenal insufficiency is a rare disorder that results from etiological factors affecting either the hypothalamic-pituitary axis or the adrenal gland itself. Studies have associated an inherently increased risk of cardiovascular ... -
Nonphysician Out-of-Hospital Rapid Sequence Intubation Success and Adverse Events: A Systematic Review and Meta-Analysis
( Elsevier , 2017 , Article)Study objective: Rapid sequence intubation performed by nonphysicians such as paramedics or nurses has become increasingly common in many countries; however, concerns have been stated in regard to the safe use and ... -
Novel biomarkers for potential risk stratification of drug induced liver injury (DILI): A narrative perspective on current trends
( Lippincott Williams and Wilkins , 2019 , Article)Background:Drug induced liver injury (DILI) is an increasing cause of acute liver injury especially with increasing need for pharmacotherapy of widening comorbidities amongst our ever-aging population. Uncertainty however ... -
A novel deep learning technique for morphology preserved fetal ECG extraction from mother ECG using 1D-CycleGAN
( Elsevier , 2024 , Article)The non-invasive fetal electrocardiogram (fECG) enables easy detection of developing heart abnormalities, leading to a significant reduction in infant mortality rate and post-natal complications. Due to the overlapping of ... -
Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers
( MDPI , 2019 , Article)As the majority of cancers and gestational diseases are prognostically stage- and grade-dependent, the ultimate goal of ongoing studies in precision medicine is to provide early and timely diagnosis of such disorders. These ... -
Novel green synthesis of Boswellia serrata leaf aqueous extract conjugated gold nanoparticles with excellent anti-acute myeloid leukemia property in comparison to mitoxantrone in a leukemic mice model: Introducing a new chemotherapeutic drug
( Wiley , 2019 , Article)© 2019 John Wiley & Sons, Ltd. The present research confirms the capacity of aqueous extract of Boswellia serrata grown under in vitro condition for the green synthesis of gold nanoparticles (AuNPs). Also, we showed the ... -
A novel in ovo model to study cancer metastasis using chicken embryos and GFP expressing cancer cells.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2019 , Article)Cancer metastasis is the leading cause of cancer-related mortality worldwide. To date, several in vitro methodologies have been developed to understand the mechanisms of cancer metastasis and to screen various therapeutic ... -
Novel nitrogen-based chalcone analogs provoke substantial apoptosis in HER2-positive human breast cancer cells via JNK and ERK1/ERK2 signaling pathways
( MDPI , 2021 , Article)Natural chalcones possess antitumor properties and play a role as inducers of apoptosis, antioxidants and cytotoxic compounds. We recently reported that novel nitrogen chalcone-based compounds, which were generated in our ... -
Novel polymethoxylated chalcones as potential compounds against kras-mutant colorectal cancers
( Bentham Science Publishers , 2020 , Article)Background/Objective: KRAS-mutant colorectal cancers (CRC) are tumors that are associated with poor prognosis. However, no effective treatments are available to target them. Therefore, we designed and synthesized novel ... -
Novel Post-translational Modifications in Human Serum Albumin
( Bentham , 2022 , Article)Aim: This study aims to identify novel post-translational modifications in human serum albumin by mass spectrometry. Background: Serum albumin is the most abundant protein in plasma, has many physiological functions, and ... -
Novel regulators of PD-L1 expression in cancer: CMTM6 and CMTM4-a new avenue to enhance the therapeutic benefits of immune checkpoint inhibitors.
( AME Publishing Company , 2017 , Article)CMTM6 and CMTM4-a new avenue to enhance the therapeutic benefits of immune checkpoint inhibitors -
Novel targetable biomarkers in clear cell carcinoma of the breast uncovered by molecular profiling: A study of nine cases.
( Wiley , 2020 , Article)We profiled nine pure clear cell carcinomas of the breast using massively parallel DNA and RNA sequencing (NGS), in situ hybridization (ISH), and immunohistochemistry (IHC). All cases were primary mammary clear cell ... -
Novel therapeutic targets in salivary duct carcinoma uncovered by comprehensive molecular profiling.
( Wiley Open Access , 2019 , Article)Salivary duct carcinoma (SDC) is a rare, aggressive salivary gland malignancy, which often presents at an advanced stage. A proportion of SDC are characterized by HER2 amplification and/or overexpression of androgen receptor ... -
Novel whole-cell inactivated Neisseria gonorrhoeae microparticles as vaccine formulation in microneedle-based transdermal immunization
( MDPI AG , 2018 , Article)Neisseria gonorrhoeae is a strict human pathogen responsible for more than 100 million new sexually transmitted infections worldwide each year. Due to the global emergence of antibiotic resistance, the Center for Disease ...