Search
Now showing items 11-20 of 46
Selective Activation of G protein-coupled Estrogen Receptor 1 Attenuates Atherosclerosis.
(
Bentham Science Publishers
, 2023 , Article Review)
Atherosclerosis remains a leading contributor to cardiovascular disease-associated morbidity and mortality. Interestingly, the death rate is higher in men than women from atherosclerosis, and the risk increases for ...
Drug Repurposing in Vasculo-metabolic Diseases
(
Bentham Science Publishers
, 2023 , Other)
Drug repurposing or repositioning is an approach that seeks to maximize the use of existing drugs by identifying
new indications other than the ones for which the drug was initially conceived [1-5]. This approach has been ...
Intake of Caffeine Containing Sugar Diet Remodels Gut Microbiota and Perturbs Drosophila melanogaster Immunity and Lifespan
(
Elsevier
, 2023 , Article)
The diet-microbiome-immunity axis is one among the many arms that draw up the “we are what we intake” proclamation. As such, studies on the effect of food and beverage intake on the gut environment and microbiome and on ...
Effects of Trehalose Administration in Patients with Mucopolysaccharidosis Type III.
(
Europe PMC
, 2023 , Article)
Mucopolysaccharidosis type III (MPS III) is a rare autosomal recessive lysosomal storage disease (LSD) caused by a deficiency of lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs), mainly in the ...
Nicolau syndrome following Intramuscular Diclofenac Injection: a case report and review of the literature.
(
Oxford University Press
, 2023 , Article)
Nicolau syndrome (NS), also referred as embolia cutis medicamentosa and livedo-like dermatitis, is an uncommon complication followed by drugs administered intramuscularly, intraarticularly or subcutaneously. In this case ...
MicroRNA-mediated regulation of LDL receptor: biological and pharmacological implications.
(
Europe PM
, 2023 , Article)
One of the main causes of atherosclerosis is a disruption in cellular cholesterol hemostasis. The low-density lipoprotein receptor (LDLR) is an important factor in maintaining cholesterol homeostasis by the receptor-mediated ...
Estrogen receptor and the gender bias in Raynaud's phenomenon.
(
Bentham Science Publishers
, 2023 , Other)
Cold-induced vasoconstriction is a normal physiological reaction aiming at redirecting blood into internal more vital body organs [1]. It is mediated by sympathetic release of norepinephrine as well as by local effectors ...
Angry scientists, angry analysts and angry novelists
(
Springer Nature
, 2023 , Other)
To the Editor: Professor Bonora has written a critique looking back at his career in diabetes research since the 1970s and we reflect on his critique by also looking back at our careers in clinical endocrinology (Professor ...
Response to Mindel C. Sheps: Counted, Dead or Alive
(
Lippincott Williams and Wilkins
, 2023 , Other)
It is true that when decision-making in medicine proceeds (e.g., drug A to prevent outcome Y), clinicians make use of research results that are reported in terms of estimated probabilities. Thus, Pr [Ya = 1 = 1] is the ...
Bias assessment: mQ or RoB?
(
Lippincott, Williams & Wilkins
, 2023 , Other)
In a recent paper in the journal, Stone et al. propose that JBI adopt the term risk of bias (RoB) wherever critical appraisal, study validity, method- ological quality (mQ), or methodological limitations are used. The ...