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Blood Proteomics Analysis Reveals Potential Biomarkers and Convergent Dysregulated Pathways in Autism Spectrum Disorder: A Pilot Study
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2023 , Article)
Autism spectrum disorder (ASD) is an umbrella term that encompasses several disabling neurodevelopmental conditions. These conditions are characterized by impaired manifestation in social and communication skills with ...
Molecular basis of FAAH-OUT-associated human pain insensitivity.
(
Oxford University Press
, 2023 , Article)
Chronic pain affects millions of people worldwide and new treatments are needed urgently. One way to identify novel analgesic strategies is to understand the biological dysfunctions that lead to human inherited pain ...
Applications of polydopaminic nanomaterials in mucosal drug delivery
(
Elsevier
, 2023 , Article Review)
Polydopamine (PDA) is a biopolymer with unique physicochemical properties, including free-radical scavenging, high photothermal conversion efficiency, biocompatibility, biodegradability, excellent fluorescent and theranostic ...
Ultrasound Intima-Media Complex (IMC) Segmentation Using Deep Learning Models
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2023 , Article)
Common carotid intima-media thickness (CIMT) is a common measure of atherosclerosis, often assessed through carotid ultrasound images. However, the use of deep learning methods for medical image analysis, segmentation and ...
The SARS-CoV-2 Spike Protein Activates the Epidermal Growth Factor Receptor-Mediated Signaling
(
MDPI
, 2023 , Article)
The coronavirus disease-19 (COVID-19) pandemic is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At the molecular and cellular levels, the SARS-CoV-2 uses its envelope glycoprotein, the ...
Angry scientists, angry analysts and angry novelists
(
Springer Nature
, 2023 , Other)
To the Editor: Professor Bonora has written a critique looking back at his career in diabetes research since the 1970s and we reflect on his critique by also looking back at our careers in clinical endocrinology (Professor ...
Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
(
Elsevier
, 2023 , Article)
Mice with ectopic expression of uncoupling protein-1 (UCP1) in skeletal muscle exhibit a healthy aging phenotype with increased longevity and resistance to impaired metabolic health. This may be achieved by decreasing ...
Metabolic changes after surgical fat removal: Current gaps and suggestions for future studies
(
Elsevier
, 2023 , Other)
Dear Editor,
We read with interest the letter by Seretes et al. discussing the findings and limitations of our evidence synthesis regarding the metabolic implications of surgical subcutaneous fat removal (SSFR).1 It is ...
Unveiling a Biomarker Signature of Meningioma: the Need for a Panel of Genomic, Epigenetic, Proteomic, and RNA Biomarkers to Advance Diagnosis and Prognosis
(
preprints
, 2023 , Preprint)
Meningiomas are the most prevalent primary intracranial tumors. The majority are benign but can undergo dedifferentiation in grades classified from I to III. Meningiomas tremendous variability in tumor behavior and slow ...
Biological applications of imiquimod analogues: An update (Review)
(
Spandidos Publications
, 2023 , Article Review)
The last decade witnessed intensive efforts in drug discovery and the emergence of thousands of molecules with potential for use as therapeutic targets. However, only a few hundred of these molecules reached the stage of ...