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المؤلفShaito, Abdullah
المؤلفAl-Mansoob, Maryam
المؤلفAhmad, Salma M S
المؤلفHaider, Mohammad Z
المؤلفEid, Ali H
المؤلفPosadino, Anna Maria
المؤلفPintus, Gianfranco
المؤلفGiordo, Roberta
تاريخ الإتاحة2022-11-21T06:36:24Z
تاريخ النشر2022-10-12
اسم المنشورCurrent Neuropharmacology
المعرّفhttp://dx.doi.org/10.2174/1570159X20666221012122855
الاقتباسShaito Abdullah, Al-Mansoob Maryam, Ahmad M.S Salma, Haider Z. Mohammad, Eid H. Ali, Posadino Maria Anna, Pintus Gianfranco*, Giordo Roberta, Resveratrol-mediated regulation of mitochondria biogenesis-associated pathways in neurodegenerative diseases: molecular insights and potential therapeutic applications, Current Neuropharmacology 2023; 21() . https://dx.doi.org/10.2174/1570159X20666221012122855
الرقم المعياري الدولي للكتاب1570-159X
معرّف المصادر الموحدhttp://hdl.handle.net/10576/36559
الملخصNeurodegenerative disorders include neurological conditions that affect nerve cells, causing the progressive loss of their functions and ultimately leading to loss of mobility, coordination, and mental functioning. The molecular mechanisms underpinning neurodegenerative disease pathogenesis are still unclear. Nonetheless, several experimental pieces of evidence demonstrate that the perturbation of mitochondrial function and dynamics plays an essential role. In this context, mitochondrial biogenesis, the growth, and division of preexisting mitochondria, by controlling mitochondria number, plays a vital role in maintaining proper mitochondrial mass and function, thus ensuring efficient synaptic activity and brain function. Mitochondrial biogenesis is tightly associated with the control of cell division and variations in energy demand in response to extracellular stimuli; therefore, it may represent a promising therapeutic target for developing new curative approaches to prevent or counteract neurodegenerative disorders. Accordingly, several inducers of mitochondrial biogenesis have already been proposed as pharmacological targets for treating diverse central nervous system conditions. The naturally occurring polyphenol resveratrol has been shown to promote mitochondrial biogenesis in various tissues, including the nervous tissue, and an ever-growing number of studies highlight its neuro-therapeutic potential. Besides preventing cognitive impairment and neurodegeneration through its antioxidant and anti-inflammatory properties, resveratrol has been shown to be able to enhance mitochondria biogenesis by acting on its main effectors, including PGC-1α, SIRT1, AMPK, ERRs, TERT, TFAM, NRF-1 and NRF-2. This review aims to present and discuss the current findings concerning the impact of resveratrol on the machinery and main effectors modulating mitochondrial biogenesis in the context of neurodegenerative diseases.
اللغةen
الناشرBentham Science Publisher
الموضوعMitochondria
Mitochondrial biogenesis
Neurodegenerative diseases
Polyphenols
Resveratrol
central nervous system
العنوانResveratrol-mediated regulation of mitochondria biogenesis-associated pathways in neurodegenerative diseases: molecular insights and potential therapeutic applications.
النوعArticle Review
رقم المجلد21
ESSN1875-6190
dc.accessType Abstract Only


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