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AuthorShaito, Abdullah
AuthorAl-Mansoob, Maryam
AuthorAhmad, Salma M S
AuthorHaider, Mohammad Z
AuthorEid, Ali H
AuthorPosadino, Anna Maria
AuthorPintus, Gianfranco
AuthorGiordo, Roberta
Available date2022-11-21T06:36:24Z
Publication Date2022-10-12
Publication NameCurrent Neuropharmacology
Identifierhttp://dx.doi.org/10.2174/1570159X20666221012122855
CitationShaito Abdullah, Al-Mansoob Maryam, Ahmad M.S Salma, Haider Z. Mohammad, Eid H. Ali, Posadino Maria Anna, Pintus Gianfranco*, Giordo Roberta, Resveratrol-mediated regulation of mitochondria biogenesis-associated pathways in neurodegenerative diseases: molecular insights and potential therapeutic applications, Current Neuropharmacology 2023; 21() . https://dx.doi.org/10.2174/1570159X20666221012122855
ISSN1570-159X
URIhttp://hdl.handle.net/10576/36559
AbstractNeurodegenerative disorders include neurological conditions that affect nerve cells, causing the progressive loss of their functions and ultimately leading to loss of mobility, coordination, and mental functioning. The molecular mechanisms underpinning neurodegenerative disease pathogenesis are still unclear. Nonetheless, several experimental pieces of evidence demonstrate that the perturbation of mitochondrial function and dynamics plays an essential role. In this context, mitochondrial biogenesis, the growth, and division of preexisting mitochondria, by controlling mitochondria number, plays a vital role in maintaining proper mitochondrial mass and function, thus ensuring efficient synaptic activity and brain function. Mitochondrial biogenesis is tightly associated with the control of cell division and variations in energy demand in response to extracellular stimuli; therefore, it may represent a promising therapeutic target for developing new curative approaches to prevent or counteract neurodegenerative disorders. Accordingly, several inducers of mitochondrial biogenesis have already been proposed as pharmacological targets for treating diverse central nervous system conditions. The naturally occurring polyphenol resveratrol has been shown to promote mitochondrial biogenesis in various tissues, including the nervous tissue, and an ever-growing number of studies highlight its neuro-therapeutic potential. Besides preventing cognitive impairment and neurodegeneration through its antioxidant and anti-inflammatory properties, resveratrol has been shown to be able to enhance mitochondria biogenesis by acting on its main effectors, including PGC-1α, SIRT1, AMPK, ERRs, TERT, TFAM, NRF-1 and NRF-2. This review aims to present and discuss the current findings concerning the impact of resveratrol on the machinery and main effectors modulating mitochondrial biogenesis in the context of neurodegenerative diseases.
Languageen
PublisherBentham Science Publisher
SubjectMitochondria
Mitochondrial biogenesis
Neurodegenerative diseases
Polyphenols
Resveratrol
central nervous system
TitleResveratrol-mediated regulation of mitochondria biogenesis-associated pathways in neurodegenerative diseases: molecular insights and potential therapeutic applications.
TypeArticle Review
Volume Number21
ESSN1875-6190
dc.accessType Abstract Only


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