College of Medicine: Recent submissions

Now showing items 781-800 of 1517

    • Neurotrauma investigation through spatial omics guided by mass spectrometry imaging: Target identification and clinical applications 

      Mallah, Khalil; Zibara, Kazem; Kerbaj, Coline; Eid, Ali; Khoshman, Nour; ... more authors ( Wiley , 2023 , Article Review)
      Traumatic brain injury (TBI) represents one of the major public health concerns worldwide due to the increase in TBI incidence as a result of injuries from daily life accidents such as sports and motor vehicle transportation ...

    • A possible role for inducible arginase isoform (AI) in the pathogenesis of chronic venous leg ulcer 

      Abd El-Aleem, Seham A.; Abd-Elghany, Manal Ismail; Ali Saber, Entesar; Jude, Edward B.; Djouhri, Laiche ( Wiley , 2020 , Article)
      Chronic venous ulcer (CVU) is a major cause of chronic wounds of lower extremities and presents a significant financial and resource burden to health care systems worldwide. Defects in the vasculature, matrix deposition, ...

    • Therapeutic effects of statins on osteoarthritis: A review 

      Saberianpour, Shirin; Abolbashari, Samaneh; Modaghegh, Mohamad H.S.; Karimian, Maryam S.; Eid, Ali H.; ... more authors ( Wiley , 2022 , Article Review)
      Osteoarthritis (OA) is a progressive joint disease. The etiology of OA is considered to be multifactorial. Currently, there is no definitive treatment for OA, and the existing treatments are not very effective. ...

    • Clinical presentation and outcomes of peripartum cardiomyopathy in the Middle East: a cohort from seven Arab countries 

      Salam, Amar M.; Ahmed, Mohamed Badie; Sulaiman, Kadhim; Singh, Rajvir; Alhashemi, Mohammed; ... more authors ( Wiley , 2020 , Article)
      Aims: Published data on the clinical presentation of peripartum cardiomyopathy (PPCM) are very limited particularly from the Middle East. The aim of this study was to examine the clinical presentation, management, and ...

    • Isolation and identification in human blood serum of the proteins possessing the ability to bind with 48 kDa form of unconventional myosin 1c and their possible diagnostic and prognostic value 

      Starykovych, Marina; Antonyuk, Volodymyr; Nehrych, Tetyana; Negrych, Nazar; Horák, Daniel; ... more authors ( Wiley , 2021 , Article)
      We firstly identified 48 kDa molecular form of the unconventional myosin 1c (p48/Myo1C), and isolated it from blood serum of multiple sclerosis patients. The amount of p48/Myo1C in human blood serum correlated with some ...

    • Novel Post-translational Modifications in Human Serum Albumin 

      Kannan, Surya; Krishnankutty, Roopesh; Souchelnytskyi, Serhiy ( Bentham , 2022 , Article)
      Aim: This study aims to identify novel post-translational modifications in human serum albumin by mass spectrometry. Background: Serum albumin is the most abundant protein in plasma, has many physiological functions, and ...

    • Targeted and systemic insights into the crosstalk between DNA-dependent protein kinase catalytic subunit and receptors of estrogen, progesterone and epidermal growth factor in the context of cancer 

      Ansari, Soubiya Mohammed Rizwan; Hijazi, Farah Saleh; Souchelnytskyi, Serhiy ( Springer , 2021 , Article)
      DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has emerged as a regulator of carcinogenesis. Increased expression of DNA-PKcs correlates with metastatic cancers. Here we review recently reported crosstalk of ...

    • Ultrasound controlled paclitaxel releasing system—A novel method for improving the availability of coronary artery drug coated balloon 

      Song, Caixia; Zhou, Chao; Zhang, Junwei; Feng, Xiangyi; Cui, Xiaoshan; ... more authors ( Wiley , 2020 , Article)
      Objectives: The aim of this study is to improve local-drug delivery efficiency and tissue absorption using the ultrasound (US)-responsible drug coating based on a newly developed US-controlled paclitaxel release balloon. ...

    • Association of Habitual Alcohol Intake with Risk of Cardiovascular Disease 

      Biddinger, Kiran J.; Emdin, Connor A.; Haas, Mary E.; Wang, Minxian; Hindy, George; ... more authors ( American Medical Association , 2022 , Article)
      Importance: Observational studies have consistently proposed cardiovascular benefits associated with light alcohol consumption, while recent genetic analyses (ie, mendelian randomization studies) have suggested a possible ...

    • Sociocultural insights on dementia care-giving in Arab and Muslim communities: The perspectives of family care-givers 

      Hammad, Suzanne H.; Daher-Nashif, Suhad; Kane, Tanya; Al-Wattary, Noor ( Cambridge University Press , 2022 , Article)
      Little is known about the experiences of informal family care-giving for persons with ADRD in the context of Arab and Muslim communities. This paper offers fresh insight into the less-studied private sphere of the home, ...

    • NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs 

      Posadino, Anna Maria; Erre, Gian Luca; Cossu, Annalisa; Emanueli, Costanza; Eid, Ali H.; ... more authors ( Walter de Gruyter , 2022 , Article)
      Systemic sclerosis (SSc) is an immune disorder characterized by diffuse fibrosis and vascular abnormalities of the affected organs. Although the etiopathology of this disease is largely unknown, endothelial damage and ...

    • Screening for diabetes and impaired glucose metabolism in Qatar: Models’ development and validation 

      Khaled, Sadek; Abdelhafez, Ibrahim; Al-Hashimi, Israa; Al-Shafi, Wadha; Tarmizi, Fatihah; ... more authors ( Elsevier , 2021 , Article)
      AimTo establish two scoring models for identifying individuals at risk of developing Impaired Glucose Metabolism (IGM) or Type two Diabetes Mellitus (T2DM) in Qatari. Materials and methodsA sample of 2000 individuals, from ...

    • Review of Post-translational Modification of Human Serum Albumin 

      Kannan, Surya; Souchelnytskyi, Serhiy ( Bentham , 2022 , Article)
      Post-translational modifications (PTMs) may affect the functions of human serum albumin. Here we review reports of novel PTMs of human serum albumin. This study reviewed one hundred twenty-three recently reported novel ...

    • Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes 

      George, Hindy; Dornbos, Peter; Chaffin, Mark D.; Liu, Dajiang J.; Wang, Minxian; ... more authors ( Elsevier , 2022 , Article)
      Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele ...

    • High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury 

      Stanley, Ibeh; Bakkar, Nour-Mounira Z.; Ahmad, Fatima; Nwaiwu, Judith; Barsa, Chloe; ... more authors ( Elsevier , 2023 , Article)
      AimsTraumatic brain injury (TBI) constitutes a serious public health concern. Although TBI targets the brain, it can exert several systemic effects which can worsen the complications observed in TBI subjects. Currently, ...

    • Diagnostic Value of Non-invasive Liver Function Tests in Liver Fibrosis and Changes in These Parameters Post-metabolic Surgery 

      Jangjoo, Sara; Emami, Nima; Sahranavard, Mehrdad; Shah, Najeeb Z.; Alidadi, Mona; ... more authors ( Springer , 2023 , Article)
      Purpose: This study aimed to ascertain the diagnostic accuracy of non-invasive liver function tests in liver fibrosis and assess their changes after metabolic surgery. Materials and Methods: 1005 individuals with severe ...

    • Papaver Plants: Current Insights on Phytochemical and Nutritional Composition Along with Biotechnological Applications 

      Butnariu, Monica; Quispe, Cristina; Herrera-Bravo, Jesús; Pentea, Marius; Sarac, Ioan; ... more authors ( Hindawi , 2022 , Article)
      The genus Papaver is highly esteemed in the pharmacy industry, in the culinary field, and as ornamental plants. These plants are also valued in traditional medicine. Among all Papaver species, Papaver somniferum L. (opium ...

    • Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations. 

      Ramli, Iman; Posadino, Anna Maria; Giordo, Roberta; Fenu, Grazia; Fardoun, Manal; ... more authors ( MDPI , 2023 , Article Review)
      Adverse pregnancy outcomes are considered significant health risks for pregnant women and their offspring during pregnancy and throughout their lifespan. These outcomes lead to a perturbated in-utero environment that impacts ...

    • G protein estrogen receptor as a potential therapeutic target in Raynaud’s phenomenon 

      Fardoun, Manal; Mondello, Stefania; Kobeissy, Firas; Eid, Ali H. ( Frontiers Media , 2022 , Article)
      Exaggerated cold-induced vasoconstriction can precipitate a pathogenesis called Raynaud’s phenomenon (RP). Interestingly, RP is significantly more prevalent in females than age-matched men, highlighting the potential ...

    • Estrogen receptor and the gender bias in Raynaud's phenomenon. 

      Fardoun, Manal; Kobeissy, Firas; Eid, Ali ( Bentham Science Publishers , 2023 , Article)
      Cold-induced vasoconstriction is a normal physiological reaction aiming at redirecting blood into internal more vital body organs [1]. It is mediated by sympathetic release of norepinephrine as well as by local effectors ...