Biomedical Research Center Research: Recent submissions

Now showing items 521-540 of 785

    • Performance evaluation of five ELISA kits for detecting anti-SARS-COV-2 IgG antibodies 

      Hadi M., Yassine; Al-Jighefee, Hadeel; Al-Sadeq, Duaa W.; Dargham, Soha R.; Younes, Salma N.; ... more authors ( Elsevier , 2020 , Article)
      ObjectivesTo evaluate and compare the performances of five commercial ELISA assays (EDI, AnshLabs, Dia.Pro, NovaTec, and Lionex) for detecting anti-SARS-CoV-2 IgG. Methods70 negative control samples (collected before the ...

    • Metabolomics of lean/overweight insulin resistant females reveals alterations in steroids and fatty acids. 

      Diboun, Ilhame; Al-Mansoori, Layla; Al-Jaber, Hend; Albagha, Omar; Elrayess, Mohamed A ( Endocrine Society , 2020 , Article)
      The global diabetes epidemic is largely attributed to obesity-triggered metabolic syndrome. However, the impact of insulin resistance (IR) prior to obesity on the high prevalence of diabetes and the molecular mediators ...

    • Growth factor loaded in situ photocrosslinkable poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/gelatin methacryloyl hybrid patch for diabetic wound healing 

      Augustine, Robin; Hasan, Anwarul; Dalvi, Yogesh B.; Rehman, Syed Raza Ur; Varghese, Ruby; ... more authors ( Elsevier , 2021 , Article)
      © 2020 The Authors Management of chronic diabetic ulcers remains as a major challenge in healthcare which requires extensive multidisciplinary approaches to ensure wound protection, management of excess wound exudates and ...

    • Application of a flow-induced stress wave and investigation of associated injuries on cell monolayers using a parallel plate flow chamber 

      Shurbaji, Samar; Al-Ruweidi, Mahmoud Khatib A.A.; Ali, Fatma Hassan; Benslimane, Fatiha M.; Yalcin, Huseyin C. ( MDPI , 2020 , Article)
      © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Parallel plate flow chambers are widely used to expose cultured cells to physiological flows for the investigation of a variety of diseases. These applications ...

    • Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model 

      Da'as, Sahar I.; Yalcin, Huseyin C.; Nasrallah, Gheyath K.; Mohamed, Iman A.; Nomikos, Michail; ... more authors ( Wiley , 2020 , Article)
      © 2020 Wiley Periodicals, Inc. Myosin-binding protein C 3 (MYBPC3) variants are the most common cause of hypertrophic cardiomyopathy (HCM). HCM is a complex cardiac disorder due to its significant genetic and clinical ...

    • A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway 

      Sartelli, Massimo; Kluger, Yoram; Ansaloni, Luca; Carlet, Jean; Brink, Adrian; ... more authors ( Mary Ann Liebert Inc. , 2017 , Article)
      This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use ...

    • Water-Pipe Smoking Exposure Deregulates a Set of Genes Associated with Human Head and Neck Cancer Development and Prognosis. 

      López-Ozuna, Vanessa M; Gupta, Ishita; Kiow, Ryan Liu Chen; Matanes, Emad; Kheraldine, Hadeel; ... more authors ( MDPI , 2020 , Article)
      Water-pipe smoking (WPS) is becoming the most popular form of tobacco use among the youth, especially in the Middle East, replacing cigarettes rapidly and becoming a major risk of tobacco addiction worldwide. Smoke from ...

    • Metabolic profiling of pre-gestational and gestational diabetes mellitus identifies novel predictors of pre-term delivery. 

      Diboun, Ilhame; Ramanjaneya, Manjunath; Majeed, Yasser; Ahmed, Lina; Bashir, Mohammed; ... more authors ( BMC , 2020 , Article)
      Pregnant women with gestational diabetes mellitus (GDM) or type 2 diabetes mellitus (T2DM) are at increased risks of pre-term labor, hypertension and preeclampsia. In this study, metabolic profiling of blood samples collected ...

    • Co-incidence of Human Papillomaviruses and Epstein-Barr Virus Is Associated With High to Intermediate Tumor Grade in Human Head and Neck Cancer in Syria. 

      Gupta, Ishita; Ghabreau, Lina; Al-Thawadi, Hamda; Yasmeen, Amber; Vranic, Semir; ... more authors ( Frontiers Media , 2020 , Article)
      High-risk human papillomaviruses (high-risk HPVs) have been recently reported to be co-present with Epstein-Barr virus (EBV) in different types of human cancers including head and neck (HN), where they can cooperate in the ...

    • Calreticulin regulates Src kinase in osteogenic differentiation from embryonic stem cells 

      Zahra, Alvandi; Al-Mansoori, Layla J.R; Opas, Michal ( Elsevier , 2020 , Article)
      Calreticulin, the major Ca2+ buffer of the endoplasmic reticulum plays an important role in the choice of fate by embryonic stem cells. Using the embryoid body method of organogenesis, we showed impaired osteogenesis in ...

    • Elaeagnus angustifolia Plant Extract Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis via HER2 Inactivation and JNK Pathway in HER2-Positive Breast Cancer Cells 

      Jabeen, Ayesha; Sharma, Anju; Gupta, Ishita; Kheraldine, Hadeel; Vranic, Semir; ... more authors ( MDPI , 2020 , Article)
      Elaeagnus angustifolia (EA) is a medicinal plant used for treating several human diseases in the Middle East. Meanwhile, the outcome of extract on HER2-positive breast cancer remains nascent. Thus, we herein investigated ...

    • Design of hybrid clay/ polypyrrole decorated with silver and zinc oxide nanoparticles for anticorrosive and antibacterial applications 

      Khouloud, Jlassi; Sliem, Mostafa H.; Benslimane, Fatiha M.; Eltai, Nahla O.; Abdullah, Aboubakr M. ( Elsevier , 2020 , Article)
      In this work, a novel and cost-effective bentonite intercalated with polypyrrole Zinc oxide-silver nanocomposite (B-PPy/ZnO) hybrid material was prepared via in situ photopolymerization of pyrrole in the presence of silanized ...

    • Inter-Versus Intra-Host Sequence Diversity of pH1N1 and Associated Clinical Outcomes 

      Al Khatib, Hebah A.; Al Maslamani, , Muna A.; V. Coyle, Peter; Thompson, I. Richard Thompson; A. Farag, Elmoubasher; ... more authors ( MDPI , 2020 , Article)
      The diversity of RNA viruses dictates their evolution in a particular host, community or environment. Here, we reported within- and between-host pH1N1virus diversity at consensus and sub-consensus levels over a three-year ...

    • Identification of mcr-8 in Clinical Isolates From Qatar and Evaluation of Their Antimicrobial Profiles 

      Eltai, Nahla O; Kelly, Brianna; Al-Mana, Hassan A.; Ibrahimhim, Emad B.; Yassine, Hadi M; ... more authors ( Frontiers Media , 2020 , Article)
      This study was performed to investigate the genotypic causes of colistin resistance in 18 colistin-resistant Klebsiella pneumoniae (n = 13), Escherichia coli (n = 3) and Pseudomonas aeruginosa (n = 2) isolates from patients ...

    • Covid-19: Challenges & Perspectives 

      Al-Emadi, Talal; Bouras, Abdelaziz; Doi, Suhail; Tang, Patrick; Benslimane, Fatiha; ... more authors ( College of Medicine - Qatar University , 2020 , Conference)
      A Virtual Conference to shed light on the QU's prominent trends and research efforts addressing Corona virus.

    • Materials Against COVID-19: How Materials Science can Impact the Pandemic? 

      Lamprou, Dimitrios; Liu, Xinyu; Ballard, Zach; Yalcin, Huseyin C; Meredith, Carson; ... more authors ( Emergent Materials Journal - Qatar University , 2020 , Video)
      This webinar aims to gather scientists, clinicians, and industry experts working on coronavirus (COVID-19). The focus of the event is a variety of material science applications for detection, prevention, and treatment of ...

    • Detection of SARS-CoV-2 RNA by direct RT-qPCR on nasopharyngeal specimens without extraction of viral RNA. 

      Hasan, Mohammad Rubayet; Mirza, Faheem; Al-Hail, Hamad; Sundararaju, Sathyavathi; Xaba, Thabisile; ... more authors ( Public Library of Science , 2020 , Article)
      To circumvent the limited availability of RNA extraction reagents, we aimed to develop a protocol for direct RT-qPCR to detect SARS-CoV-2 in nasopharyngeal swabs without RNA extraction. Nasopharyngeal specimens positive ...

    • Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses. 

      Boyoglu-Barnum, Seyhan; Hutchinson, Geoffrey B; Boyington, Jeffrey C; Moin, Syed M; Gillespie, Rebecca A; ... more authors ( Nature Research , 2020 , Article)
      The conserved hemagglutinin (HA) stem has been a focus of universal influenza vaccine efforts. Influenza A group 1 HA stem-nanoparticles have been demonstrated to confer heterosubtypic protection in animals; however, the ...

    • Loop-mediated isothermal amplification (Lamp): A rapid, sensitive, specific, and cost-effective point-of-care test for coronaviruses in the context of covid-19 pandemic 

      Augustine, Robin; Hasan, Anwarul; Das, Suvarthi; Ahmed, Rashid; Mori, Yasuyoshi; ... more authors ( MDPI , 2020 , Article)
      The rampant spread of COVID-19 and the worldwide prevalence of infected cases demand a rapid, simple, and cost-effective Point of Care Test (PoCT) for the accurate diagnosis of this pandemic. The most common molecular tests ...

    • Combined chemo-magnetic field-photothermal breast cancer therapy based on porous magnetite nanospheres 

      Sharifi, Majid; Hasan, Anwarul; Nanakali, Nadir Mustafa Qadir; Salihi, Abbas; Qadir, Fikry Ali; ... more authors ( Nature Research , 2020 , Article)
      The efficacy of different modalities of treating breast cancer is inhibited by several limitations such as off-targeted drug distribution, rapid drug clearance, and drug resistance. To overcome these limitations, we developed ...