Browsing Biomedical Sciences by Title
Now showing items 336-355 of 712
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Identification of potential inhibitors against pathogenic missense mutations of PMM2 using a structure-based virtual screening approach.
( Taylor & Francis , 2019 , Article)The autosomal recessive phosphomannomutase 2-congenital disorder of glycosylation (PMM2-CDG) is characterized by defective functioning of the PMM2 enzyme, which is necessary for the conversion of mannose-6-phosphate into ... -
Identification of Potential Inhibitors Targeting GTPase-Kirsten RAt Sarcoma Virus (K-Ras) Driven Cancers via E-Pharmacophore-Based Virtual Screening and Drug Repurposing Approach
( IMR Press Limited , 2023 , Article)Background: Mutations in the K-Ras gene are among the most frequent genetic alterations in various cancers, and inhibiting RAS signaling has shown promising results in treating solid tumors. However, finding effective drugs ... -
Identification of potential natural inhibitors of the receptor-binding domain of the SARS-CoV-2 spike protein using a computational docking approach
( Hamad Bin Khalifa University Press , 2021 , Article)The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only zoonotic-origin CoV to reach the pandemic stage, to which neither an effective vaccine nor a specific therapy is available. The spike ... -
Identification of potential natural inhibitors of the receptor-binding domain of the SARS-CoV-2 spike protein using a computational docking approach
( HBKU Press , 2021 , Article)Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only zoonotic-origin CoV to reach the pandemic stage, to which neither an effective vaccine nor a specific therapy is available. The ... -
Identification of Prognostic Metabolomic Biomarkers at the Interface of Mortality and Morbidity in Pre-Existing TB Cases Infected With SARS-CoV-2
( Frontiers Media S.A. , 2022 , Article)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection currently remains one of the biggest global challenges that can lead to acute respiratory distress syndrome (CARDS) in severe cases. In line with this, ... -
Identification of the Main Intermediate Precursor of l-Ergothioneine Biosynthesis in Human Biological Specimens
( MDPI AG , 2016 , Article)A capillary electrophoresis coupled to tandem mass spectrometry (CE–MS/MS) has been used to make a qualitative determination of hercynine—the main precursor of l-ergothioneine biosynthesis—in some key human biological ... -
Imaging Patterns in Breast Cancer for Women Under 40 Years: A Descriptive Cohort Study
( Springer Nature , 2024 , Article)Background and Aim: Breast cancer is the most frequently occurring malignant disease in women and remains the leading cause of cancer-related deaths among females worldwide. The aim of this study is to evaluate the imaging ... -
Immune Imprinting and Protection against Repeat Reinfection with SARS-CoV-2
( Massachusetts Medical Society , 2022 , Other)More than 2 years into the coronavirus disease 2019 (Covid-19) pandemic, the global population carries heterogeneous immune histories derived from various exposures to infection, viral variants, and vaccination.1 Evidence ... -
Immune Modulatory Effects of Vitamin D on Viral Infections.
( MDPI , 2020 , Article)Viral infections have been a cause of mortality for several centuries and continue to endanger the lives of many, specifically of the younger population. Vitamin D has long been recognized as a crucial element to the ... -
Immune stimulatory effect of Nigella sativa in healthy animal models: A systematic review and meta-analysis
( Elsevier Ltd , 2024 , Article)The immune-modulatory effects of black seeds (Nigella sativa seeds, NSS) are well documented, but the overall in vivo impact of this important natural medicinal product on immune system function has yet to be established. ... -
Immunogenetics of Celiac Disease: A focus on Arab countries.
( Bentham Science Publishers , 2019 , Article)Celiac Disease (CD) is a complex immunogenic disease mainly triggered by gluten intake in genetically susceptible individuals with a prevalence of 1 in 100-300. CD results from the interplay between genetic and environmental ... -
Immunoinformatics prediction of potential immunodominant epitopes from human coronaviruses and association with autoimmunity
( Springer Science and Business Media Deutschland GmbH , 2022 , Article)Cross-reactivity between different human coronaviruses (HCoVs) might contribute to COVID-19 outcomes. Here, we aimed to predict conserved peptides among different HCoVs that could elicit cross-reacting B cell and T cell ... -
Immunomodulation Induced by Host Pathogen Interaction
( Hindawi , 2019 , Article)Controlling and preventing infections require deep understanding of the complex interplay that occurs between the host and pathogen following infection. In essence, immunomodulation is any process leading to an immune ... -
Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19
( IMR Press , 2022 , Article Review)Natural products with known safety profiles are a promising source for the discovery of new drug leads. Berberine presents an example of one such phytochemical that has been extensively studied for its anti-inflammatory ... -
Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions.
( Taylor and Francis , 2021 , Article)Inflammation is associated with the development and progression of various disorders including atherosclerosis, diabetes mellitus and cancer. Sesamin, a fat-soluble lignan derived from seeds and oil, has received increased ... -
Immunomodulatory effects of vitamin d supplementation in a deficient population
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)In addition to its canonical functions, vitamin D has been proposed to be an important mediator of the immune system. Despite ample sunshine, vitamin D deficiency is prevalent (>80%) in the Middle East, resulting in a high ... -
Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects
( MDPI , 2022 , Article)Infants who are exclusively breastfed in the first six months of age receive adequate nutrients, achieving optimal immune protection and growth. In addition to the known nutritional components of human breast milk (HBM), ... -
The Immunophenotyping Changes of Peripheral CD4+ T Lymphocytes and Inflammatory Markers of Class III Obesity Subjects After Laparoscopic Gastric Sleeve Surgery - A Follow-Up Study
( Dovepress , 2021 , Article)Obesity is a chronic disorder characterized by a low-grade inflammatory state and immune cell irregularities. The study aimed to follow up on the changes in the peripheral CD4+ T lymphocytes and the pro-inflammatory ... -
The Impact of Environmental and Anthropogenic Factors on the Transmission Dynamics of Vector Borne Diseases
( Elsevier , 2019 , Article)Vector-borne diseases have been widely associated with human morbidity and mortality. The predominance of vector-borne diseases is not exclusive to particular areas, as such diseases are dispersed across the globe. Generally, ... -
The impact of microbial composition on postprandial glycaemia and lipidaemia: A systematic review of current evidence
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Postprandial hyperglycaemia is associated with increased risk of cardiovascular disease. Recent studies highlight the role of the gut microbiome in influencing postprandial glycaemic (PPG) and lipidaemic (PPL) responses. ...