Tumor-type agnostic, targeted therapies make a new step forward: The first tumor-agnostic approval of a HER2-targeted therapy
الملخص
Oncologic treatment has recently undergone substantial therapeutic paradigm shifts, from classical tumor-specific and biomarker-agnostic approaches to more molecular, biomarker-specific, and tumor-agnostic. Tumor-type (histology) agnostic drugs work across cancer types and present a novel shift in precision oncology. Compared with traditional cancer therapies, this novel approach implies molecularly informed treatment strategies and enables targeted treatment regardless of tumor histology (type). Such drugs are usually utilized in small clinical cohorts with diverse tumor types sharing a common genomic event (molecular biomarker). One of the key elements of this approach is the presence of a common biomarker across many tumor types. Biomarker predicts response to the targeted drugs, as well as deciphers potential resistance mechanisms.
المجموعات
- أبحاث الطب [1412 items ]
وثائق ذات صلة
عرض الوثائق المتصلة بواسطة: العنوان، المؤلف، المنشئ والموضوع.
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Current Technologies and Future Perspectives in Immunotherapy towards a Clinical Oncology Approach
Adhikary, Subhamay; Pathak, Surajit; Palani, Vignesh; Acar, Ahmet; Banerjee, Antara; Al-Dewik, Nader I.; Essa, Musthafa Mohamed; Mohammed, Sawsan G.A.A.; Qoronfleh, M. Walid... more authors ... less authors ( MDPI , 2024 , Article Review)Immunotherapy is now established as a potent therapeutic paradigm engendering antitumor immune response against a wide range of malignancies and other diseases by modulating the immune system either through the stimulation ... -
Current Technologies and Future Perspectives in Immunotherapy towards a Clinical Oncology Approach
Adhikary, Subhamay; Pathak, Surajit; Palani, Vignesh; Acar, Ahmet; Banerjee, Antara; Al-Dewik, Nader I.; Essa, Musthafa M.; Mohammed, Sawsan G. A. A.; Qoronfleh, M. Walid... more authors ... less authors ( MDPI , 2024 , Article Review)Immunotherapy is now established as a potent therapeutic paradigm engendering antitumor immune response against a wide range of malignancies and other diseases by modulating the immune system either through the stimulation ... -
In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy
Al-Mansoori, Layla; Bashraheel, Sara S; Qahtani, Alanod D Al; O'Connor, C David; Elsinga, Philip; Goda, Sayed K... more authors ... less authors ( Impact Journals , 2020 , Article)The sequence asparagine-glycine arginine (NGR), flanked by Cysteine (Cys) residues so as to form a disulfide-bridge (CNGRC), has previously been found to target and bind specifically to aminopeptidase N (APN), which is ...