Impact of bariatric surgery on circulating irisin levels: a systematic review and meta‑analysis
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Date
2024-05-14Author
Jamialahamdi, TannazMirhadi, Elaheh
Almahmeed, Wael
Eid, Ali H.
Al-Rasadi, Khalid
Nguyen, Ninh T.
Gadde, Kishore M.
Sahebkar, Amirhossein
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This systematic review and meta-analysis evaluated changes in circulating irisin levels after bariatric surgery. A systematic search was performed across Embase, Scopus, PubMed, and Web of Science for this study. The meta-analysis was conducted using Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was depicted through a random-effects meta-analysis and the leave-one-out method. The meta-analysis, which included 13 studies with a total of 407 participants, showed a statistically non-significant reduction in circulating irisin levels following bariatric surgery (SMD: – 0.089, 95% CI – 0.281, 0.102, 95% PI: – 0.790, 0.611, p = 0.360; I2:70.56). Our research found no significant change in irisin levels after bariatric surgery. Moreover, these findings were not associated with the type of surgery or the duration of follow-up.
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