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المؤلفMahmoud, Nouf N.
المؤلفZakaria, Zain Zaki
المؤلفKheraldine, Hadeel
المؤلفGupta, Ishita
المؤلفVranic, Semir
المؤلفAl-Asmakh, Maha
المؤلفMoustafa, Ala Eddin Al
تاريخ الإتاحة2021-10-26T06:47:17Z
تاريخ النشر2021-10-01
اسم المنشورInternational Journal of Molecular Sciences
المعرّفhttp://dx.doi.org/10.3390/ijms222011036
الاقتباسMahmoud, N.N.; Zakaria, Z.Z.; Kheraldine, H.; Gupta, I.; Vranic, S.; Al-Asmakh, M.; Al Moustafa, A.-E. The Effect of Surface-Modified Gold Nanorods on the Early Stage of Embryonic Development and Angiogenesis: Insight into the Molecular Pathways. Int. J. Mol. Sci. 2021, 22, 11036. https://doi.org/10.3390/ijms222011036
الرقم المعياري الدولي للكتاب16616596
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85117002503&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/24692
الملخصGold nanorods have been implicated in several biomedical applications. Herein, the effect of two surface-modified gold nanorods on the early stages of embryogenesis and angiogenesis was investigated using avian embryos at three days and their chorioallantoic membrane (CAM) at five days of incubation. We found that gold nanorods (GNR) modified with PEGylated phospholipid moiety show a high mortality rate in embryos after four days of exposure compared to GNR modified with PEGylated cholesterol moiety. Meanwhile, our data revealed that surface modified-GNR significantly inhibit the formation of new blood vessels in the treated CAM model after 48 h of exposure. Moreover, we report that surface-modified GNR significantly deregulate the expression of several genes implicated in cell proliferation, invasion, apoptosis, cellular energy metabolism, and angiogenesis. On the other hand, our data point out that GNR treatments can modulate the expression patterns of JNK1/2/3, NF-KB/p38, and MAPK, which could be the main molecular pathways of the nanorods in our experimental models.
راعي المشروعThis research was funded by the following Qatar University Grant: (QUCG-CMED-20/21-2) and the Deanship of Scientific Research at Al-Zaytoonah University of Jordan (2020–2019/12/28)
اللغةen
الناشرMDPI
الموضوعAngiogenesis
Apoptosis
Chick chorioallantoic membrane
Embryogenesis
Gold nanorods
العنوانThe effect of surface-modified gold nanorods on the early stage of embryonic development and angiogenesis: Insight into the molecular pathways
النوعArticle
رقم العدد20
رقم المجلد22
ESSN1422-0067
dc.accessType Open Access


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