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    Comparison of antibody immune responses between BNT162b2 and mRNA-1273 SARS-CoV-2 vaccines in naïve and previously infected individuals.

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    Comparison of antibody immune responses between BNT162b2 and mRNA-1273 SARS-CoV-2 vaccines in naïve and previously infected individuals.pdf (463.7Kb)
    Date
    2021-12-29
    Author
    Al-Sadeq, Duaa W
    Shurrab, Farah M
    Ismail, Ahmed
    Amanullah, Fathima Humaira
    Thomas, Swapna
    Aldewik, Nader
    Yassine, Hadi M
    Abdul Rahim, Hanan F
    Abu-Raddad, Laith
    Nasrallah, Gheyath K
    ...show more authors ...show less authors
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    Abstract
    Two mRNA vaccines, Pfizer-BNT162b2 and Moderna-mRNA-1273, obtained the Emergency Use Listing by WHO for preventing COVID-19. However, little is known about the difference in antibody responses induced by these two mRNA vaccines in naïve and previously infected (PI) individuals. We investigated the levels of anti-S-RBD (total, IgG and IgA) levels in naïve and PI individuals, 1-13 (median = 6) weeks following the second dose of either vaccine. Results in the naïve-vaccinated group, the mRNA-1273 vaccine induced significantly higher levels of anti-S-RBD total antibodies (3.5-fold; P < 0.001), IgG (2-fold, P < 0.01) and IgA (2.1-fold, P < 0.001) as compared with the BNT162b2 vaccine. In addition, both vaccines produced significantly higher anti-S-RBD total antibody levels in the PI-group compared with naïve-vaccinated group. The PI group elicited a higher level of anti-S-RBD IgG than the naïve-BNT162b2 (P = 0.05), but not more than the naïve-mRNA-1273 (P = 0.9) group. Interestingly, the PI vaccinated group elicited a comparable level of IgA ratio to the naïve-mRNA-1273 group but significantly higher than the naïve-BNT162b2 group (1.6-fold, P < 0.001). Our results showed that the PI-vaccinated group produces a higher level of antibodies than the naïve vaccinated group, particularly for those vaccinated with BNT162b2.
    DOI/handle
    http://dx.doi.org/10.1093/jtm/taab190
    http://hdl.handle.net/10576/25665
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    • Biological & Environmental Sciences [‎933‎ items ]
    • Biomedical Research Center Research [‎808‎ items ]
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    • COVID-19 Research [‎849‎ items ]

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