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Association of physical activity level during pregnancy with preterm birth and infant adiposity: longitudinal analysis from the MAASTHI cohort, India
( Springer Nature , 2025 , Article)Background: Physical activity during pregnancy is thought to influence birth outcomes, but its association with it is not fully understood. We aimed to examine the association of sedentary behavior during pregnancy with ... -
The impact of pre-existing immunity on the emergence of within-host immune-escape mutations in Omicron lineages
( Microbiology Society , 2025 , Article)The Omicron variant of SARS-CoV-2 circulating amongst highly immunized populations is anticipated to induce immunological pressures, potentially compromising existing immunity. This study investigates vaccine-induced ... -
Prospective registration was associated with a reduced risk of bias for randomized controlled trials: a meta-research study
( Elsevier , 2025 , Article)ObjectivesTo investigate the association between trial registration and the risk of bias (RoB). Study Design and SettingsRandomized controlled trials (RCTs) from systematic reviews of medication-related harm published ... -
Shaping the future of cell and gene therapy workforce development: training of cell therapy processing personnel - perspectives from the International Society for Cell & Gene Therapy Lab Practices Committee
( Elsevier , 2025 , Article)BackgroundThe field of cell and gene therapy (CGT) is expanding at a rapid rate. CGT workforce shortage is a growing concern, and high-quality training programs are essential to keep up with the increasing demand for ... -
Proteomic analysis reveals potential biomarker candidates in serous ovarian tumors – a preliminary study
( Termedia Publishing House Ltd. , 2025 , Article)Introduction: Ovarian serous cystadenocarcinoma (SCA), a deadly gynecologic cancer, often goes undetected until the late stages. Tissue proteomics unveils disease heterogeneity, enhancing tumor classification and enabling ... -
Size Increment During Surveillance in Papillary Thyroid Cancer: Evidence Synthesis and Dose–Response Meta-Analysis
( John Wiley & Sons , 2025 , Article)Introduction: Differentiated thyroid cancer has become a prevalent malignant tumor, particularly papillary thyroid carcinoma (PTC), constituting over 90% of cases. Most PTC lesions are asymptomatic and remain subclinical ... -
Reply to Editorial Comment on “Hypospadias Reconstruction Training: Development of an Ex-Vivo Model for Objective Evaluation of Surgical Skills”
( Elsevier , 2025 , Article)W e sincerely appreciate the thoughtful feedback provided. The objective nature of the comments aligns closely with the goals of our work. As noted, this study1 was primarily aimed at evaluating technical skills in a ... -
Risk of Serious Infections in Patients Treated With Biologic or Targeted-synthetic Disease Modifying Antirheumatic Drugs in Qatar
( John Wiley & Sons , 2025 , Article)Background: Biologic and targeted-synthetic disease-modifying antirheumatic drugs (b/tsDMARDs), are pivotal in the management of autoimmune-inflammatory disorders, acting by suppressing pathological immune activation. ... -
Effects of perinatal variables on echocardiographic assessments of left ventricular dimensions in infants born large for gestational age: a prospective cohort analysis
( Springer Nature , 2025 , Article)Background: To assess the relationship between perinatal factors, and echocardiographic left ventricular (LV) dimensions after delivery in infants who are large for gestational age (LGA). Methods: This prospective cohort ... -
The disease-linked R336C mutation in cystathionine β-synthase disrupts communication with the PLP cofactor, yet maintains the enzyme's overall structural integrity
( John Wiley & Sons , 2025 , Article)Cystathionine β-synthase (CBS) is a pyridoxal-phosphate (PLP)-dependent enzyme essential for the reverse transsulfuration pathway, where homocysteine and serine combine to form cystathionine, the immediate precursor of ... -
Cross-Organ Investigation of Tumor Histological Features Similarities Using Transfer Learning: A Case Study on Breast and Colorectal Tumors
( Springer Science and Business Media Deutschland GmbH , 2025 , Conference)Breast and colorectal cancers are two of the most commonly occurring cancers in the world. Transfer Learning with models pre-trained on ImageNet has been extensively used in the literature in the detection of these two ... -
A multicenter mixed-methods study on the effects of intermittent fasting in patients with immune thrombocytopenia receiving thrombopoietin receptor agonists
( Frontiers Media SA , 2025 , Article)Introduction: In recent years, significant advances have been made in the treatment of immune thrombocytopenia (ITP) with the development of thrombopoietin receptor agonists (TPO-RAs). TPO-RAs are often used following the ... -
Long-term renal function post-pyeloplasty: a systematic review
( Springer Science and Business Media B.V. , 2025 , Article Review)Introduction: Ureteropelvic junction obstruction (UPJO) is a significant cause of functional impairment in neonatal kidneys. The gold-standard surgical intervention for UPJO is pyeloplasty, which offers good preservation ... -
Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1? Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background: Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1). For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional ... -
Delivery of PLGA-Loaded Influenza Vaccine Microparticles Using Dissolving Microneedles Induces a Robust Immune Response
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background: Influenza virus is one of the major respiratory virus infections that is a global health concern. Although there are already approved vaccines, most are administered via the intramuscular route, which is usually ... -
Holistic precision wellness: Paving the way for next-generation precision medicine (ngPM) with AI, biomedical informatics, and clinical medicine
( John Wiley and Sons Inc , 2025 , Article)A "quiet revolution" in medicine has been taking place over the past two decades. There are two converging dynamic forces that have propelled precision medicine to the limelight, garnering wide public attention. The first ... -
Combining dopamine and vitamin E enhances the differentiation to cholinergic neurons of mesenchymal stem cells
( Oxford University Press , 2025 , Article)Recent research indicates that mesenchymal stem cells (MSCs) can transdifferentiate into neuron-like cells under specific conditions, offering promise for neuronal regeneration. However, challenges remain in optimizing ... -
Establishing a Structured Hypospadias Biobank Cohort for Integrated Research: Methodology, Comprehensive Database Integration, and Phenotyping
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background/Objectives: Hypospadias, a common congenital anomaly in males, presents significant challenges in diagnosis, management, and long-term care. Despite its prevalence, research into the condition has been hampered ... -
Fueling Inner Resources Through Co-Creation: A Scoping Review on the Impact of Co-Creation of Education on Learners' Well-Being
( Ubiquity Press , 2025 , Article Review)Introduction: Co-creation is gaining momentum in health professions education with positive effects on learners' engagement and motivation. Concurrently, emotional challenges faced by learners-such as stress, anxiety, ... -
Implementing a chest tube removal protocol in patients with thoracic trauma: a prospective clinical study
( AME Publishing Company , 2025 , Article)Background: Timing of chest tube removal in trauma patients is debatable. This study aimed to assess whether protocolized early thoracostomy tube (TT) removal is associated with better outcomes. The study hypothesis is ...
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