Browsing by Author "Crovella, Sergio"
Now showing items 21-40 of 44
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Host Response of Syrian Hamster to SARS-CoV-2 Infection including Differences with Humans and between Sexes
Castellan, Martina; Zamperin, Gianpiero; Franzoni, Giulia; Foiani, Greta; Zorzan, Maira; Drzewnioková, Petra; Mancin, Marzia; Brian, Irene; Bortolami, Alessio; Pagliari, Matteo; Oggiano, Annalisa; Vascellari, Marta; Panzarin, Valentina; Crovella, Sergio; Monne, Isabella; Terregino, Calogero; De Benedictis, Paola; Leopardi, Stefania... more authors ... less authors ( MDPI , 2023 , Article)The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted the importance of having proper tools and models to study the pathophysiology of emerging infectious diseases to test therapeutic ... -
Human Defensins from Antivirals to Vaccine Adjuvants: Rediscovery of the Innate Immunity Arsenal
Zupin, Luisa; Crovella, Sergio ( Bentham Science Publishers , 2022 , Other)Human defensins are a class of antimicrobial peptides, belonging to the innate immunity system. These peptides are expressed at the level of respiratory tract (both upper and lower) where they represent the first line of ... -
Impact of Sample Preparation Methods on Single-Cell X-ray Microscopy and Light Elemental Analysis Evaluated by Combined Low Energy X-ray Fluorescence, STXM and AFM
Merolle, Lucia; Pascolo, Lorella; Zupin, Luisa; Parisse, Pietro; Bonanni, Valentina; Gariani, Gianluca; Kenig, Sasa; Bedolla, Diana E.; Crovella, Sergio; Ricci, Giuseppe; Iotti, Stefano; Malucelli, Emil; Kourousias, George; Gianoncelli, Alessandra... more authors ... less authors ( MDPI , 2023 , Article)BACKGROUND: Although X-ray fluorescence microscopy is becoming a widely used technique for single-cell analysis, sample preparation for this microscopy remains one of the main challenges in obtaining optimal conditions for ... -
In silico-designed antimicrobial peptide targeting MRSA and E. coli with antibacterial and antibiofilm actions
Madni, Hafsa; Mohamed, Hana A.; Abdelrahman, Hana Adel Mohamed; dos Santos-Silva, Carlos André; Benko-Iseppon, Ana Maria; Khatir, Zenaba; Eltai, Nahla O.; Mohamed, Nura A.; Crovella, Sergio... more authors ... less authors ( Springer Nature , 2024 , Article)Antibiotic resistance is a paramount global health issue, with numerous bacterial strains continually fortifying their resistance against diverse antibiotics. This surge in resistance levels primarily stems from the overuse ... -
A loss-of-function NCSTN mutation associated with familial Dowling Degos disease and hidradenitis suppurativa
de Oliveira, Ana Sofia Lima Estevao; de Siqueira, Roberta Cardoso; Nait-Meddour, Cécile; Tricarico, Paola Maura; Moura, Ronald; Agrelli, Almerinda; d'Adamo, Adamo Pio; Jamain, Stéphane; Crovella, Sergio; de Fátima Medeiros Brito, Maria; Boniotto, Michele; Brandão, Lucas André Cavalcanti... more authors ... less authors ( Wiley , 2023 , Article)Dowling Degos disease (DDD) is a rare autosomal dominant genodermatosis characterized by acquired, slowly progressive reticulated pigmented lesions primarily involving flexural skin areas. Mutations in KRT5, POGLUT-1 and ... -
Microalgae potential to protect from heavy metals-induced carcinogenicity
Hadjira, Hamai-Amara; Abou-Saleh, Haissam; A. Al-Ghouti, Mohammad; Crovella, Sergio; Saadaoui, Imen; Soubra, Lama... more authors ... less authors ( Elsevier , 2024 , Article)Toxic elements are present naturally in the environment; however, during the last century, their level has been continuously rising in the air, water, and soil due to anthropogenic activities, including urban runoff, ... -
The mitochondrial-related effect of the 905 nm photobiomodulation therapy on 50B11 sensory neurons
Zupin, Luisa; Crovella, Sergio; Milena, Cadenaro; Barbi, Egidio; Celsi, Fulvio ( Wiley , 2023 , Article)Photobiomodulation therapy (PBMT) is known as a complementary tool to alleviate pain sensation in patients, nevertheless, there is still a gap of knowledge on its mechanism of action, thus limiting its clinical employment. ... -
Molecular analysis of inflammatory diseases.
Almughrbi, Aya Hamad; Crovella, Sergio ( Wiley , 2022 , Article Review)If we try to describe the search for molecular actors involved in inflammatory diseases, the picture best representing this task is a mission to unexplored worlds. However, researchers nowadays have powerful tools to support ... -
Nanomedicine as a Potential Tool against Monkeypox.
Mohamed, Nura Adam; Zupin, Luisa; Mazi, Sarah Ismail; Al-Khatib, Hebah A; Crovella, Sergio ( MDPI , 2023 , Article Review)Human monkeypox is a rare viral zoonosis that was first identified in 1970; since then, this infectious disease has been marked as endemic in central and western Africa. The disease has always been considered rare and ... -
Optimization of Anti-SARS-CoV-2 Treatments Based on Curcumin, Used Alone or Employed as a Photosensitizer.
Zupin, Luisa; Fontana, Francesco; Clemente, Libera; Borelli, Violetta; Ricci, Giuseppe; Ruscio, Maurizio; Crovella, Sergio... more authors ... less authors ( MDPI , 2022 , Article)Curcumin, the bioactive compound of the spice , has already been reported as a potential COVID-19 adjuvant treatment due to its immunomodulatory and anti-inflammatory properties. In this study, SARS-CoV-2 was challenged ... -
An overview of Zika virus genotypes and their infectivity
Bernardo-Menezes, Lucas Coêlho; Agrelli, Almerinda; de Oliveira, Ana Sofia Lima Estevão; de Moura, Ronald Rodrigues; Crovella, Sergio; Brandão, Lucas André Cavalcanti... more authors ... less authors ( Sociedade Brasileira de Medicina Tropical , 2022 , Article Review)Zika virus (ZIKV) is an enveloped, single-stranded RNA arbovirus belonging to the genus Flavivirus. It was first isolated from a sentinel monkey in Uganda in 1947. More recently, ZIKV has undergone rapid geographic expansion ... -
Paraviral cutaneous manifestations associated to SARS-CoV-2 Omicron variant
Zupin, Luisa; Moltrasio, Chiara; Tricarico, Paola Maura; Del Vecchio, Cecilia; Fontana, Francesco; Marzano, Angelo Valerio; Crovella, Sergio... more authors ... less authors ( Taylor and Francis Group , 2022 , Article)Background: The spreading of the SARS-CoV-2 Omicron variant is probably due to its increased transmissibility and ability to escape from neutralising antibodies. Cutaneous manifestations have been reported after infection ... -
A rare loss-of-function genetic mutation suggest a role of dermcidin deficiency in hidradenitis suppurativa pathogenesis
Tricarico, Paola Maura; Gratton, Rossella; Santos-Silva, Carlos André dos; Moura, Ronald Rodrigues de; Ura, Blendi; Sommella, Eduardo; Campiglia, Pietro; Del Vecchio, Cecilia; Moltrasio, Chiara; Berti, Irene; D’Adamo, Adamo Pio; Elsherbini, Ahmed M.A.; Staudenmaier, Lena; Chersi, Karin; Boniotto, Michele; Krismer, Bernhard; Schittek, Birgit; Crovella, Sergio... more authors ... less authors ( Frontiers Media , 2022 , Article)Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a multifactorial aetiology that involves a strict interplay between genetic factors, immune dysregulation and lifestyle. Familial forms represent ... -
SARS-CoV-2 does not replicate in HaCaT spontaneously immortalized human keratinocytes: implications for the pathogenesis of COVID-19-associated skin manifestations
Zupin, Luisa; Moltrasio, Chiara; Genovese, Giovanni; Milani, Margherita; Fontana, Francesco; Ruscio, Maurizio; Valerio Marzano, Angelo; Crovella, Sergio... more authors ... less authors ( John Libbey Eurotext , 2022 , Article)Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-related cutaneous manifestations have been reported [1], however, the direct or indirect role of SARS-CoV-2 infection in their pathophysiology is still debated ... -
SARS-CoV-2 modulates virus receptor expression in placenta and can induce trophoblast fusion, inflammation and endothelial permeability
Agostinis, Chiara; Toffoli, Miriam; Spazzapan, Mariagiulia; Balduit, Andrea; Zito, Gabriella; Mangogna, Alessandro; Zupin, Luisa; Salviato, Tiziana; Maiocchi, Serena; Romano, Federico; Crovella, Sergio; Fontana, Francesco; Braga, Luca; Confalonieri, Marco; Ricci, Giuseppe; Kishore, Uday; Bulla, Roberta... more authors ... less authors ( Frontiers Media , 2022 , Article)SARS-CoV-2 is a devastating virus that induces a range of immunopathological mechanisms including cytokine storm, apoptosis, inflammation and complement and coagulation pathway hyperactivation. However, how the infection ... -
SARS-CoV-2 RNA Recovery from Air Sampled on Quartz Fiber Filters: A Matter of Sample Preservation?
Licen, Sabina; Zupin, Luisa; Martello, Lorenzo; Torboli, Valentina; Semeraro, Sabrina; Gardossi, Anna Lilian; Greco, Enrico; Fontana, Francesco; Crovella, Sergio; Ruscio, Maurizio; Palmisani, Jolanda; Di Gilio, Alessia; Piscitelli, Prisco; Pallavicini, Alberto; Barbieri, Pierluigi... more authors ... less authors ( MDPI , 2022 , Report)The airborne route of transmission of SARS-CoV-2 was confirmed by the World Health Organization in April 2021. There is an urge to establish standardized protocols for assessing the concentration of SARS-CoV-2 RNA in air ... -
Think like a Virus: Toward Improving Nanovaccine Development against SARS-CoV-2
Mohamed, Nura A.; Abou-Saleh, Haissam; Mohamed, Hana A.; Al-Ghouti, Mohammad A.; Crovella, Sergio; Zupin, Luisa... more authors ... less authors ( MDPI , 2022 , Article Review)There is no doubt that infectious diseases present global impact on the economy, society, health, mental state, and even political aspects, causing a long-lasting dent, and the situation will surely worsen if and when the ... -
Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling
de Oliveira, Ana Sofia Lima Estevao; Bloise, Giovanna; Moltrasio, Chiara; Coelho, Antonio; Agrelli, Almerinda; Moura, Ronald; Tricarico, Paola Maura; Jamain, Stéphane; Marzano, Angelo Valerio; Crovella, Sergio; Cavalcanti Brandão, Lucas André... more authors ... less authors ( MDPI , 2022 , Article)Hidradenitis suppurativa (HS) is an inflammatory skin condition clinically characterized by recurrent painful deep-seated nodules, abscesses, and sinus tracks in areas bearing apocrine glands, such as axillae, breasts, ... -
Transient Receptor Potential Ankyrin 1 (TRPA1) Methylation and Chronic Pain: A Systematic Review
Celsi, Fulvio; Peri, Francesca; Cavasin, Julia; Zupin, Luisa; Cozzi, Giorgio; Barbi, Egidio; Crovella, Sergio... more authors ... less authors ( MDPI , 2023 , Other)Background and Objective: Chronic pain represents a major global health issue in terms of psycho-physiological, therapeutic, and economic burden, not limited to adults but also to the pediatric age. Despite its great impact, ... -
Unraveling the Role of Sex Hormones on Keratinocyte Functions in Human Inflammatory Skin Diseases
Gratton, Rossella; Del Vecchio, Cecilia; Zupin, Luisa; Crovella, Sergio ( MDPI , 2022 , Article Review)The skin exerts several fundamental functions that are the first physical, chemical and immune barriers to the human body. Keratinocytes, the main cell type of the epidermis, provide mechanical defense, support skin integrity ...