SARS-CoV-2 Infection and Smoking: What is the association? A brief review
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التاريخ
2021-03-23المؤلف
Ishita, GuptaSohail, Muhammad Umar
Elzawawi, Khaled E.
Amarah, Ahmed H.
Vranic, Semir
Al-Asmakh, Maha
Moustafa, Ala-Eddin Al
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البيانات الوصفية
عرض كامل للتسجيلةالملخص
Susceptibility to severe illness from COVID-19 is anticipated to be associated with cigarette smoking as it aggravates the risk of cardiovascular and respiratory illness, including infections. This is particularly important with the advent of a new strain of coronaviruses, the severe acute respiratory syndrome coronavirus (SARS-CoV-2) that has led to the present pandemic, coronavirus disease 2019 (COVID-19). Although, the effects of smoking on COVID-19 are less described and controversial, we presume a link between smoking and COVID-19. Smoking has been shown to enhance the expression of the angiotensin-converting enzyme-2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) key entry genes utilized by SARS-CoV-2 to infect cells and induce a ‘cytokine storm’, which further increases the severity of COVID-19 clinical course. Nevertheless, the impact of smoking on ACE-2 and TMPRSS2 receptors expression remains paradoxical. Thus, further research is necessary to unravel the association between smoking and COVID-19 and to pursue the development of potential novel therapies that are able to constrain the morbidity and mortality provoked by this infectious disease. Herein we present a brief overview of the current knowledge on the correlation between smoking and the expression of SARS-CoV-2 key entry genes, clinical manifestations, and disease progression.
معرّف المصادر الموحد
https://www.sciencedirect.com/science/article/pii/S2001037021000957?v=s5المجموعات
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