SARS-CoV-2 Infection and Smoking: What is the association? A brief review
Author | Ishita, Gupta |
Author | Sohail, Muhammad Umar |
Author | Elzawawi, Khaled E. |
Author | Amarah, Ahmed H. |
Author | Vranic, Semir |
Author | Al-Asmakh, Maha |
Author | Moustafa, Ala-Eddin Al |
Available date | 2021-03-29T10:08:43Z |
Publication Date | 2021-03-23 |
Publication Name | Computational and Structural Biotechnology Journal |
Identifier | http://dx.doi.org/10.1016/j.csbj.2021.03.023 |
Citation | Gupta, I., Sohail, M. U., Elzawawi, K. E., Amarah, A. H., Vranic, S., Al-Asmakh, M., & Al Moustafa, A. E. (2021). SARS-CoV-2 Infection and Smoking: What is the association? A brief review. Computational and Structural Biotechnology Journal. |
ISSN | 20010370 |
Abstract | Susceptibility to severe illness from COVID-19 is anticipated to be associated with cigarette smoking as it aggravates the risk of cardiovascular and respiratory illness, including infections. This is particularly important with the advent of a new strain of coronaviruses, the severe acute respiratory syndrome coronavirus (SARS-CoV-2) that has led to the present pandemic, coronavirus disease 2019 (COVID-19). Although, the effects of smoking on COVID-19 are less described and controversial, we presume a link between smoking and COVID-19. Smoking has been shown to enhance the expression of the angiotensin-converting enzyme-2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) key entry genes utilized by SARS-CoV-2 to infect cells and induce a ‘cytokine storm’, which further increases the severity of COVID-19 clinical course. Nevertheless, the impact of smoking on ACE-2 and TMPRSS2 receptors expression remains paradoxical. Thus, further research is necessary to unravel the association between smoking and COVID-19 and to pursue the development of potential novel therapies that are able to constrain the morbidity and mortality provoked by this infectious disease. Herein we present a brief overview of the current knowledge on the correlation between smoking and the expression of SARS-CoV-2 key entry genes, clinical manifestations, and disease progression. |
Language | en |
Publisher | Elsevier |
Subject | SARS-CoV-2 Coronavirus COVID-19 Smoking Lung Disease Oral Disease |
Type | Article |
Open Access user License | http://creativecommons.org/licenses/by/4.0/ |
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