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المؤلفZakaria, Zain Zaki
المؤلفAladwi, Shaima Ahmad
المؤلفBenslimane, Fatiha
المؤلفAl-Absi, Enas S.
المؤلفAl-Shafai, Mashael
المؤلفYalcin, Huseyin C.
المؤلفKhalil, Ashraf
المؤلفAl Moustafa, Ala-Eddin
المؤلفAl-Asmakh, Maha
تاريخ الإتاحة2021-11-08T05:56:20Z
تاريخ النشر2021-11-06
اسم المنشورInternational Journal of Environmental Research and Public Health
المعرّفhttp://dx.doi.org/10.3390/ijerph182111659
الاقتباسZakaria, Z.Z.; Aladwi, S.A.; Benslimane, F.; Al-Absi, E.S.; Al-Shafai, M.; Yalcin, H.C.; Khalil, A.; Moustafa, A.-E.A.; Al-Asmakh, M. Effect of Water-Pipe Smoking on the Normal Development of Zebrafish. Int. J. Environ. Res. Public Health 2021, 18, 11659. https://doi.org/10.3390/ ijerph182111659
معرّف المصادر الموحدhttp://hdl.handle.net/10576/24860
الملخصBackground: Among all types of tobacco consumption,Water-Pipe Smoking (WPS) is the most widely used in the Middle East and second-most in several other countries. The effect of WPS on normal development is not yet fully understood, thus the aim of this study is to explore the acute toxicity effects of WPS extract on zebrafish larvae. Methods: In this study, we compared the effects of WPS smoke condensates at concentrations varying from 50 to 200 g/mL on developmental, cardiac, and behavioural (neurotoxicity) functions. Gene expression patterns of cardiac biomarkers were also evaluated by RT-qPCR. Results: Exposing zebrafish embryos to 50, 100, 150 and 200 g/mL WPS for three days did not affect the normal morphology of Zebrafish embryos, as the tail flicking, behavioural and locomotion assays did not show any change. However, WPS deregulated cardiac markers including atrial natriuretic peptide (ANP/NPPA) and brain natriuretic peptide (BNP/NPPB). Furthermore, it induced apoptosis in a dose-dependent manner. Conclusion: Our data demonstrate that WPS can significantly affect specific cardiac parameters during the normal development of zebrafish. Further investigations are necessary to elucidate the pathogenic outcome of WPS on different aspects of human life, including pregnancy.
راعي المشروعThis research was funded by Qatar University -internal grants, grant numbers QUCP-CHS-2019-1, IRCC-2021-013 and Qatar Petroleum under project number QUEX-BRC-QP-PW-18/19. The findings achieved herein are solely the responsibility of the authors.
اللغةen
الناشرMDPI
الموضوعzebrafish
waterpipe smoking
toxicity testing
developmental biology
العنوانEffect of Water-Pipe Smoking on the Normal Development of Zebrafish
النوعArticle
رقم العدد21
رقم المجلد18
ESSN1660-4601
dc.accessType Full Text


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