Browsing Medicine Research by Title
Now showing items 594-613 of 1272
-
Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders
( Wiley , 2024 , Article Review)RNA-binding proteins (RBPs) play a crucial role in the regulation of posttranscriptional RNA networks, which can undergo dysregulation in many pathological conditions. Human antigen R (HuR) is a highly researched RBP that ... -
Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers.
( Public Library of Science , 2020 , Article)Octamer binding transcription factor-4 (Oct4), is highly expressed in stem cells and has indispensable roles in pluripotency and cellular reprogramming. In contrast to other factors used for cellular reprogramming, a role ... -
Human Papillomaviruses and Epstein-Barr Virus Interactions in Colorectal Cancer: A Brief Review.
( MDPI , 2020 , Article)Human papillomaviruses (HPVs) and the Epstein-Barr virus (EBV) are the most common oncoviruses, contributing to approximately 10%-15% of all malignancies. Oncoproteins of high-risk HPVs (E5 and E6/E7), as well as EBV (LMP1, ... -
Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions.
( MDPI , 2022 , Article Review)The human papillomavirus (HPV) is a non-enveloped double-stranded DNA virus capable of infecting skin and mucosa epithelial cells. Commonly, HPV infection is associated with sexually transmitted diseases and is considered ... -
Human rights as the key driver for development of Learning Disability services in Qatar
( Elsevier , 2023 , Article)Growing international consensus in recognising rights of individuals with disability to enabling environments has spurred on provision of services for support for these individuals. The provision of this support has however ... -
Hydroxychloroquine in COVID-19 Patients: Pros and Cons
( Frontiers Media S.A. , 2020 , Article)The pandemic of COVID-19, caused by SARS-CoV-2, has recently overwhelmed medical centers and paralyzed economies. The unparalleled public distress caused by this pandemic mandated an urgent quest for an effective approach ... -
Hyperosmotic Stress Induces a Specific Pattern for Stress Granule Formation in Human-Induced Pluripotent Stem Cells
( Hindawi , 2021 , Article)Stress granules (SGs) are assemblies of selective messenger RNAs (mRNAs), translation factors, and RNA-binding proteins in small untranslated messenger ribonucleoprotein (mRNP) complexes in the cytoplasm. Evidence indicates ... -
Hypotension: An unusual presentation of vitamin B 12 deficiency, with complete recovery following cyanocobalamin therapy
( BMJ Publishing Group , 2019 , Article)Vitamin B 12 deficiency and its sequelae are well described and reported, especially in vegetarians. However, its association with haemodynamic instability is not well identified. We report a case of a young man, previously ... -
Identification of a Histone Deacetylase: Epigenetic Impact on Host Gene Expression.
( MDPI , 2020 , Article)Epigenetic reprogramming in macrophages is termed trained innate immunity, which regulates immune tolerance and limits tissue damage during infection. is a strict human pathogen that causes the sexually transmitted infection ... -
Identification of a 48 kDa form of unconventional myosin 1c in blood serum of patients with autoimmune diseases.
( Elsevier , 2016 , Article)We searched for protein markers present in blood serum of multiple sclerosis (MS), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients in comparison to healthy human individuals. We used precipitati ... -
Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function.
( Oxford University Press , 2020 , Article)The cardiac ryanodine receptor (RyR2), which mediates intracellular Ca2+ release to trigger cardiomyocyte contraction, participates in development of acquired and inherited arrhythmogenic cardiac disease. This study was ... -
Identification of Co-Deregulated Genes in Urinary Bladder Cancer Using High-Throughput Methodologies
( MDPI , 2021 , Article)Urinary bladder cancer (UBC) is the second most common urogenital solid tumor and the eleventh in the rank among all types of solid tumors. Although several oncogenes and tumor suppressors are known to be implicated in the ... -
Identification of cortactin molecular forms in human urine and their possible diagnostic value
( Palladin Institute of Biochemistry of the NASU , 2021 , Article)The protein composition of human urine reflects changes in the biochemical and physiological status of an individual and has an essential diagnostic value. Using precipitation/extraction methods we isolated a protein with ... -
Identification of FAM173B as a protein methyltransferase promoting chronic pain
( Public Library of Science , 2018 , Article)Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic ... -
Identification of potential transcription factors that enhance human iPSC generation
( Springer Nature , 2020 , Article)Although many factors have been identified and used to enhance the iPSC reprogramming process, its efficiency remains quite low. In addition, reprogramming efficacy has been evidenced to be affected by disease mutations ... -
Identification of SER-PRO-CYS Peptide in Blood Serum of Multiple Sclerosis Patients
( Bentham Science Publishers , 2016 , Article)Monitoring of multiple sclerosis (MS) requires additional molecular markers. Recently, we used original TCA-precipitation/extraction approach in combination with MALDI TOF/TOF mass-spectrometry and identified earlier unknown ... -
Identifying essential competencies for medical students
( Emerald Group Publishing Ltd. , 2019 , Article)Purpose The purpose of this paper is to identify essential profession-related competencies, clinical knowledge and skills that medical students should develop in the early stages of their education for future professional ... -
Identifying metabolic alterations in newly diagnosed small cell lung cancer patients
( Elsevier , 2021 , Article)BackgroundSmall cell lung cancer (SCLC) is a malignant disease with poor prognosis. At the time of diagnosis most patients are already in a metastatic stage. Current diagnosis is based on imaging, histopathology, and ... -
IDF Diabetes Atlas: Estimation of Global and Regional Gestational Diabetes Mellitus Prevalence for 2021 by International Association of Diabetes in Pregnancy Study Group’s Criteria
( Elsevier , 2021 , Article)AimsThe approaches used to screen and diagnose gestational diabetes mellitus (GDM) vary widely. We generated a comparable estimate of the global and regional prevalence of GDM by International Association of Diabetes in ... -
IDF Diabetes Atlas: The prevalence of pre-existing diabetes in pregnancy – A systematic reviewand meta-analysis of studies published during 2010–2020
( Elsevier , 2021 , Article)ObjectivesTo estimate the prevalence of pre-existing diabetes in pregnancy from studies published during 2010–2020. MethodsWe searched PubMed, CINAHL, Scopus and other sources for relevant data sources. The prevalence of ...