Browsing Medicine Research by Title
Now showing items 435-454 of 676
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Nanotoxicology of dendrimers in the mammalian heart: Ex vivo and in vivo administration of g6 pamam nanoparticles impairs recovery of cardiac function following ischemia-reperfusion injury
( Dove Medical Press Ltd. , 2020 , Article)Aim: The effects of polyamidoamine (PAMAM) dendrimers on the mammalian heart are not completely understood. In this study, we have investigated the effects of a sixth-generation cationic dendrimer (G6 PAMAM) on cardiac ... -
Neisseria gonorrhoeae Ketol-Acid Reductoisomerase Is a Potential Therapeutic Target
( IntechOpen , 2022 , Book chapter)The host-adapted human pathogen Neisseria gonorrhoeae is the causative agent of sexually transmitted infection gonorrhea. The increased emergence of gonorrhea infections worldwide, associated with the surging resistance ... -
Neuronal Cell Types in the Anterior Ventral Thalamic Nucleus of the Camel.
( Wiley , 2021 , Article)The anterior ventral nucleus neurons in of the camel brain were morphologically studied by Golgi impregnation method. Two neuronal types of were found in the camel anterior ventral thalamic nucleus, namely, Golgi-type I ... -
Neuropathic itch
( NLM (Medline) , 2019 , Article)Neuropathic itch is clinically important but has received much less attention as compared to neuropathic pain. In the past decade, itch-specific pathways have been characterized on a cellular and molecular level, but their ... -
Neutralizing antibodies against SARS-CoV-2 are higher but decline faster in mRNA vaccinees compared to individuals with natural infection.
( Oxford University Press , 2022 , Article)Waning protection against emerging SARS-CoV-2 variants by pre-existing antibodies elicited due to current vaccination or natural infection is a global concern. Whether this is due to the waning of immunity to SARS-COV-2 ... -
New clinical approaches and emerging evidence on immune-checkpoint inhibitors as anti-cancer therapeutics: CTLA-4 and PD-1 pathways and beyond
( Begell House Inc. , 2019 , Article)The development of immune checkpoint blockers, primarily comprising the anti-PD-1/anti-PD-L1 and anti-CTLA-4 monoclonal antibodies, has formed the therapeutic landscape of quite a few different cancer types. In spite of ... -
A new improved graphical and quantitative method for detecting bias in meta-analysis.
( Lippincott, Williams & Wilkins , 2018 , Article)Detection of publication and related biases remains suboptimal and threatens the validity and interpretation of meta-analytical findings. When bias is present, it usually differentially affects small and large studies ... -
New insight into the role of PTCH1 protein in serous ovarian carcinomas.
( Spandidos Publications , 2022 , Article)The Hedgehog (Hh) signaling pathway is essential for normal embryonic development, while its hyperactivation in the adult organism is associated with the development of various cancers. The role of the Hh signaling pathway ... -
A new method for synthesizing test accuracy data outperformed the bivariate method
( Elsevier , 2020 , Article)This paper outlines the development of a new method (split component synthesis; SCS) for meta-analysis of diagnostic accuracy studies and assesses its performance against the commonly used bivariate random effects model. ... -
Nociceptor subtypes and their incidence in rat lumbar dorsal root ganglia (DRGs): focussing on C-polymodal nociceptors, A?-nociceptors, moderate pressure receptors and their receptive field depths
( Elsevier Ltd , 2019 , Article Review)A recent study with Ca++-sensitive-dyes in neurons in whole DRGs (Table 5) found that much lower percentages of nociceptors were polymodal-nociceptors (PMNs) (Emery et al., 2016), than the 50–80% values in many ... -
The Non-Coding RNA and Its Role in Tumor Therapy-Induced Resistance.
( MDPI , 2020 , Article)The growth arrest-specific transcript 5 () is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, ... -
Nonphysician Out-of-Hospital Rapid Sequence Intubation Success and Adverse Events: A Systematic Review and Meta-Analysis
( Elsevier , 2017 , Article)Study objective: Rapid sequence intubation performed by nonphysicians such as paramedics or nurses has become increasingly common in many countries; however, concerns have been stated in regard to the safe use and ... -
Novel biomarkers for potential risk stratification of drug induced liver injury (DILI): A narrative perspective on current trends
( Lippincott Williams and Wilkins , 2019 , Article)Background:Drug induced liver injury (DILI) is an increasing cause of acute liver injury especially with increasing need for pharmacotherapy of widening comorbidities amongst our ever-aging population. Uncertainty however ... -
Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers
( MDPI , 2019 , Article)As the majority of cancers and gestational diseases are prognostically stage- and grade-dependent, the ultimate goal of ongoing studies in precision medicine is to provide early and timely diagnosis of such disorders. These ... -
Novel green synthesis of Boswellia serrata leaf aqueous extract conjugated gold nanoparticles with excellent anti-acute myeloid leukemia property in comparison to mitoxantrone in a leukemic mice model: Introducing a new chemotherapeutic drug
( Wiley , 2019 , Article)© 2019 John Wiley & Sons, Ltd. The present research confirms the capacity of aqueous extract of Boswellia serrata grown under in vitro condition for the green synthesis of gold nanoparticles (AuNPs). Also, we showed the ... -
A novel in ovo model to study cancer metastasis using chicken embryos and GFP expressing cancer cells.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2019 , Article)Cancer metastasis is the leading cause of cancer-related mortality worldwide. To date, several in vitro methodologies have been developed to understand the mechanisms of cancer metastasis and to screen various therapeutic ... -
Novel nitrogen-based chalcone analogs provoke substantial apoptosis in HER2-positive human breast cancer cells via JNK and ERK1/ERK2 signaling pathways
( MDPI , 2021 , Article)Natural chalcones possess antitumor properties and play a role as inducers of apoptosis, antioxidants and cytotoxic compounds. We recently reported that novel nitrogen chalcone-based compounds, which were generated in our ... -
Novel polymethoxylated chalcones as potential compounds against kras-mutant colorectal cancers
( Bentham Science Publishers , 2020 , Article)Background/Objective: KRAS-mutant colorectal cancers (CRC) are tumors that are associated with poor prognosis. However, no effective treatments are available to target them. Therefore, we designed and synthesized novel ... -
Novel regulators of PD-L1 expression in cancer: CMTM6 and CMTM4-a new avenue to enhance the therapeutic benefits of immune checkpoint inhibitors.
( AME Publishing Company , 2017 , Article)CMTM6 and CMTM4-a new avenue to enhance the therapeutic benefits of immune checkpoint inhibitors -
Novel targetable biomarkers in clear cell carcinoma of the breast uncovered by molecular profiling: A study of nine cases.
( Wiley , 2020 , Article)We profiled nine pure clear cell carcinomas of the breast using massively parallel DNA and RNA sequencing (NGS), in situ hybridization (ISH), and immunohistochemistry (IHC). All cases were primary mammary clear cell ...
