Search

Now showing items 1-10 of 16

Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor.

Padmanabhan, Regina; Kheraldine, Hadeel; Gupta, Ishita; Meskin, Nader; Hamad, Anas; ... more authors ... less authors ( Frontiers Media , 2022 , Article)

Immune checkpoint blockade (ICB)-based therapy is revolutionizing cancer treatment by fostering successful immune surveillance and effector cell responses against various types of cancers. However, patients with HER2+ ...

Ethanolic extract of Origanum syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties

Mesmar, Joelle; Abdallah, Rola; Hamade, Kamar; Baydoun, Serine; Al-Thani, Najlaa; ... more authors ... less authors ( Frontiers Media , 2022 , Article)

Background: Breast cancer (BC) is the second most common cancer overall. In women, BC is the most prevalent cancer and the leading cause of cancer-related mortality. Triple-negative BC (TNBC) is the most aggressive BC, ...

A comprehensive review on the antiviral activities of chalcones

Elkhalifa, Dana; Al-Hashimi, Israa; Al Moustafa, Ala-Eddin; Khalil, Ashraf ( Taylor and Francis Ltd. , 2021 , Article)

Some viral outbreaks have plagued the world since antiquity, including the most recent COVID-19 pandemic. The continuous spread and emergence of new viral diseases have urged the discovery of novel treatment options that ...

Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions.

Fernandes, Queenie; Allouch, Soumaya; Gupta, Ishita; Elmakaty, Ibrahim; Elzawawi, Khaled E; ... more authors ... less authors ( MDPI , 2022 , Article Review)

The human papillomavirus (HPV) is a non-enveloped double-stranded DNA virus capable of infecting skin and mucosa epithelial cells. Commonly, HPV infection is associated with sexually transmitted diseases and is considered ...

Effect of recombinant human erythropoietin and doxorubicin in combination on the proliferation of MCF-7 and MDA-MB231 breast cancer cells

Radwan, Esam M.; Abdullah, Rasedee; Al-Qubaisi, Mothanna Sadiq; El Zowalaty, Mohamed E.; Naadja , Seif-Eddine; ... more authors ... less authors ( Spandidos Publications , 2016 , Article)

Patients with cancer often exhibit signs of anemia as the result of the disease. Thus, cancer chemotherapies often include erythropoietin (EPO) in the regime to improve the survival rate of these patients. The aim of the ...

Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells

AlKahlout, Amal; Fardoun, Manal; Mesmar, Joelle; Abdallah, Rola; Badran, Adnan; ... more authors ... less authors ( Frontiers Media , 2022 , Article)

Breast cancer is the leading cause of cancer-related deaths among women. Among breast cancer types, triple negative breast cancer (TNBC) is the most aggressive, and is resistant to hormonal and chemotherapeutic treatments. ...

Fractionation and phytochemical composition of an ethanolic extract of Ziziphus nummularia leaves: antioxidant and anticancerous properties in human triple negative breast cancer cells

Abdallah, Rola; Shaito, Abdullah A.; Badran, Adnan; Baydoun, Serine; Sobeh, Mansour; ... more authors ... less authors ( Frontiers Media , 2024 , Article)

Natural products have long been utilized in traditional medicine as remedies to improve health and treat illnesses, and have had a key role in modern drug discovery. Recently, there has been a revived interest in the search ...

Ubiquitin-Related Modifier 1 (URM-1) Modulates Cx43 in Breast Cancer Cell Lines.

El-Hajjar, Layal; Saliba, Jessica; Karam, Mario; Shaito, Abdullah; El Hajj, Hiba; ... more authors ... less authors ( MDPI , 2023 , Article)

Gap-junction-forming connexins are exquisitely regulated by post-translational modifications (PTMs). In particular, the PTM of connexin 43 (Cx43), a tumor suppressor protein, regulates its turnover and activity. Here, we ...

Ziziphus nummularia crude and fractionated extracts attenuate the malignant phenotype of human triple-negative breast cancer cells

Shaito, Abdullah; Abdallah, Rola; Sobeh, Mansour; Sahri, Nihad; Mesmar, Joelle E.; ... more authors ... less authors ( Symposium Cracoviense , 2024 , Conference)

Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and has limited therapeutic options. Effects of Ziziphus nummularia against TNBC have not been investigated yet. An ethanolic extract of ...

Co-prevalence of Epstein-Barr virus and high-risk human papillomaviruses in Syrian women with breast cancer.

Al Moustafa, Ala-Eddin; Al-Antary, Noor; Aboulkassim, Tahar; Akil, Nizar; Batist, Gerald; ... more authors ... less authors ( Taylor & Francis , 2016 , Article)

ABSTRAT We recently performed 2 studies viewing the presence of Epstein-Barr virus (EBV) and high-risk human papillomaviruses (HPVs) types 16, 18, 31, 33 and 35 in human breast cancer in the Syrian population. Herein, we ...