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AuthorAl Hariri, Moustafa
AuthorAl-Sulaiti, Haya
AuthorAnwardeen, Najeha
AuthorNaja, Khaled
AuthorElrayess, Mohamed A.
Available date2024-08-28T04:23:43Z
Publication Date2024
Publication NameObesity
ResourceScopus
ISSN19307381
URIhttp://dx.doi.org/10.1002/oby.24070
URIhttp://hdl.handle.net/10576/58233
AbstractObjective: Measuring obesity is crucial for assessing health risks and developing effective prevention and treatment strategies. The most common methods used to measure obesity include BMI, waist circumference, and waist-hip ratio. This study aimed to determine the metabolic signatures associated with each measure of obesity in the Qatari population. Methods: Metabolomics profiling was conducted to identify, quantify, and characterize metabolites in serum samples from the study participants. Inverse rank normalization, principal component analysis, and orthogonal partial least square-discriminant analysis were used to analyze the metabolomics data. Results: This study revealed significant differences in metabolites associated with obesity based on different measurements. In men, phosphatidylcholine and phosphatidylethanolamine metabolites were significantly enriched in individuals classified as having obesity based on the waist-hip ratio. In women, significant changes were observed in leucine, isoleucine, and valine metabolism metabolites. Unique metabolites were found in the different categorization groups that could serve as biomarkers for assessing many obesity-related disorders. Conclusions: This study identified unique metabolic signatures associated with obesity based on different measurements in the Qatari population. These findings contribute to a better understanding of the molecular pathways involved in obesity and may have implications for developing personalized prevention and treatment strategies.
SponsorThis study was supported by Qatar Research and Development Innovation (QRDI) grant PPM 06\u20100516\u2010230030.
Languageen
PublisherJohn Wiley and Sons Inc
Subjectalanine aminotransferase
albumin
alkaline phosphatase
aspartate aminotransferase
bicarbonate
bilirubin
C peptide
cholesterol
creatine kinase
gamma glutamylcyclotransferase
gamma glutamyltransferase
glucose
hemoglobin A1c
high density lipoprotein cholesterol
insulin
isoleucine
leucine
low density lipoprotein cholesterol
phosphatidylcholine
phosphatidylethanolamine
retinol
saturated fatty acid
sodium
sphingomyelin
triacylglycerol
urea
uric acid
valine
xenobiotic agent
biological marker
adult
Article
blood pressure
body mass
diabetes mellitus
female
human
lipid metabolism
male
metabolite
metabolomics
obesity
principal component analysis
Qatari
systematic review
waist circumference
waist hip ratio
weight
blood
comparative study
metabolism
metabolome
metabolomics
middle aged
procedures
Adult
Biomarkers
Body Mass Index
Female
Humans
Isoleucine
Leucine
Male
Metabolome
Metabolomics
Middle Aged
Obesity
Phosphatidylcholines
Phosphatidylethanolamines
Principal Component Analysis
Waist Circumference
Waist-Hip Ratio
TitleComparing the metabolic signatures of obesity defined by waist circumference, waist-hip ratio, or BMI
TypeArticle
Pagination1494-1507
Issue Number8
Volume Number32
dc.accessType Open Access


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