Browsing Medicine Research by Title
Now showing items 715-734 of 1418
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In-frame fusion of SUMO1 enhances βarrestin2's association with activated GPCRs as well as with nuclear pore complexes
( Elsevier , 2020 , Article)Small ubiquitin like modifier (SUMO) conjugation or SUMOylation of βarrestin2 promotes its association with the clathrin adaptor protein AP2 and facilitates rapid β2 adrenergic receptor (β2AR) internalization. However, ... -
Incidence and association of high-risk HPVs and EBV in patients with advanced stages of colorectal cancer from Qatar
( Taylor and Francis Ltd. , 2023 , Article)High-risk Human Papillomaviruses (HPVs) and Epstein-Barr virus (EBV) are present and involved in several types of human carcinomas, including cervical and, head and neck cancers. Nevertheless, their presence and association ... -
Incidence of HPVs, EBV and MMTV-like Virus in Breast Cancer in Qatar.
( Karger Publishers , 2022 , Article)Human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and mouse mammary tumor virus-like virus (MMTV-like virus) can be present and contribute to breast cancer development and progression. However, the role of these ... -
Incidence, clinical features, and outcomes of posterior circulation ischemic stroke: insights from a large multiethnic stroke database
( Frontiers Media SA , 2024 , Article)Background: Posterior cerebral circulation ischemic stroke (PCS) comprises up to 25% of all strokes. It is characterized by variable presentation, leading to misdiagnosis and morbidity and mortality. We aim to describe PCS ... -
Increased cellular protein modification by methylglyoxal activates endoplasmic reticulum-based sensors of the unfolded protein response
( Elsevier B.V. , 2024 , Article)The unfolded protein response (UPR) detects increased misfolded proteins and activates protein refolding, protein degradation and inflammatory responses. UPR sensors in the endoplasmic reticulum, IRE1α and PERK, bind and ... -
Increased de novo DNA methylation enzymes in sperm of individuals with varicocele
( pmc , 2021 , Article)Objective: Chronic genital heat-stress associated with varicocele leads to DNA hypo-methylation of spermatozoa. The objective of this study was comparing level of DNA methyl-transferases (DNMTs) in sperm of men suffering ... -
Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis
( American Society for Clinical Investigation , 2022 , Article)People with kidney disease are disproportionately affected by atherosclerosis for unclear reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived mediator of kidney disease, levels of which ... -
An infant with ankyloblepharon filiforme adnatum associated with a cleft lip and palate: A case report
( Elsevier , 2022 , Other)Ankyloblepharon filiform adnatum (AFA) is a rare but potentially ambylogenic congenital anomaly characterized by a partial or complete fusion of the eyelid margins.1 Although AFA has been reported as an isolated finding, ... -
Infantile hypertrophic pyloric stenosis in Bosnia and Herzegovina: A retrospective cohort study from the largest tertiary care facility
( Elsevier , 2021 , Article)Background Infantile hypertrophic pyloric stenosis (IHPS) is the most common condition requiring surgery in infancy, but the etiology of IHPS is still unclear. The study aimed to analyze the epidemiological and clinical ... -
Infection with Helicobacter pylori may predispose to atherosclerosis: role of inflammation and thickening of intima-media of carotid arteries
( Frontiers Media , 2023 , Article Review)Atherosclerosis is a major instigator of cardiovascular disease (CVD) and a main cause of global morbidity and mortality. The high prevalence of CVD calls for urgent attention to possible preventive measures in order to ... -
Inflammasomes as biomarkers and therapeutic targets in traumatic brain injury and related-neurodegenerative diseases: A comprehensive overview
( Elsevier , 2023 , Article)Given the ambiguity surrounding traumatic brain injury (TBI) pathophysiology and the lack of any Food and Drug Administration (FDA)-approved neurotherapeutic drugs, there is an increasing need to better understand the ... -
Inflammatory protein signatures in individuals with obesity and metabolic syndrome
( Springer Nature , 2023 , Article)There is variability in the metabolic health status among individuals presenting with obesity; some may be metabolically healthy, while others may have developed the metabolic syndrome, a cluster including insulin resistance, ... -
Influence of lack of blinding on the estimation of medication-related harms: a retrospective cohort study of randomized controlled trials.
( Springer Nature , 2024 , Article)Empirical evidence suggests that lack of blinding may be associated with biased estimates of treatment benefit in randomized controlled trials, but the influence on medication-related harms is not well-recognized. We aimed ... -
The influence of maternal blood glucose during pregnancy on weight outcomes at birth and preschool age in offspring exposed to hyperglycemia first detected during pregnancy, in a South African cohort.
( Public Library of Science , 2021 , Article)Little is known about the influence of hyperglycemia first detected in pregnancy (HFDP) on weight outcomes in exposed offspring in Africa. We investigated the influence of maternal blood glucose concentrations during ... -
Information on harm outcomes was insufficiently reported in systematic reviews and meta-analyses of individual participant data
( John Wiley and Sons Inc , 2021 , Other)Meta-analysis is an important tool for summarizing findings from scientific research. But for harm outcomes,issues may arise due to the distribution problems, zero-events problems, as well as low statistical power. Individual ... -
Information, Thermodynamics and Life: A Narrative Review
( MDPI , 2021 , Article Review)Information is probably one of the most difficult physical quantities to comprehend. This applies not only to the very definition of information, but also to the physical entity of information, meaning how can it be ... -
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
( BMC , 2020 , Article)Recent studies indicated that seeded fibril formation and toxicity of α-synuclein (α-syn) play a main role in the pathogenesis of certain diseases including Parkinson's disease (PD), multiple system atrophy, and dementia ... -
Injuries related to pets, exotic animals, and falconry in Qatar
( HBKU Press , 2023 , Article)Introduction: Pets and exotic animals are increasingly popular all over the world. Some of these animals may cause injuries to their owners or other people during interactions. Both injuries and systemic infections always ... -
Inositol 1,4,5-Trisphosphate Receptors in Hypertension.
( Frontiers Media , 2018 , Article Review)Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. ... -
Intake of Caffeine Containing Sugar Diet Remodels Gut Microbiota and Perturbs Drosophila melanogaster Immunity and Lifespan
( Elsevier , 2023 , Article)The diet-microbiome-immunity axis is one among the many arms that draw up the “we are what we intake” proclamation. As such, studies on the effect of food and beverage intake on the gut environment and microbiome and on ...