Browsing Faculty Contributions by Title

Now showing items 13733-13752 of 17618

    • Sandwich structures for energy absorption applications: A review 

      Tarlochan, Faris ( MDPI AG , 2021 , Article)
      It is crucial that proper engineering structures are designed as energy absorbers for high dynamic loading situations, such as accidents, blasts, or impacts. The role of such structures is to absorb the high kinetic energy ...

    • Sanguinarine Induces Apoptosis in Papillary Thyroid Cancer Cells via Generation of Reactive Oxygen Species. 

      Khan, Abdul Q; Mohamed, Elham A N; Hakeem, Ishrat; Nazeer, Aneeza; Kuttikrishnan, Shilpa; ... more authors ( MDPI , 2020 , Article)
      Sanguinarine (SNG), a natural compound with an array of pharmacological activities, has promising therapeutic potential against a number of pathological conditions, including malignancies. In the present study, we have ...

    • Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling. 

      Akhtar, Sabah; Achkar, Iman W; Siveen, Kodappully S; Kuttikrishnan, Shilpa; Prabhu, Kirti S; ... more authors ( Frontiers Media , 2019 , Article)
      Sanguinarine (SNG), a benzophenanthridine alkaloid, has displayed various anticancer abilities in several vivo and studies. However, the anticancer potential of SNG is yet to be established in multiple myeloma (MM), a ...

    • Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia 

      Kuttikrishnan S.; Siveen K.S.; Prabhu K.S.; Khan A.Q.; Akhtar S.; ... more authors ( Taylor and Francis Ltd , 2019 , Article)
      Sanguinarine (Sang), a plant-derived compound isolated from the roots of Sanguinaria canadensis was evaluated for its potential pro-apoptotic effects in precursor B acute lymphoblastic leukemia (Pre-ALL) cell lines. Treatment ...

    • SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs 

      Shalaby, Raed; Petzer, Jacobus P.; Petzer, Anél; Ashraf, Usman M.; Atari, Ealla; ... more authors ( Taylor and Francis Ltd. , 2019 , Article)
      The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. ...

    • SARS-CoV-2 and immune-microbiome interactions: Lessons from respiratory viral infections 

      Farhan, Cyprian; Sohail, Muhammad Umar; Abdelhafez, Ibrahim; Salman, Salma; Attique, Zakria; ... more authors ( Elsevier , 2021 , Article)
      By the beginning of 2020, infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had rapidly evolved into an emergent worldwide pandemic, an outbreak whose unprecedented consequences highlighted ...

    • SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy 

      Laith J., Abu-Raddad; Chemaitelly, Hiam; Coyle, Peter; Malek, Joel A.; Ahmed, Ayeda A.; ... more authors ( Elsevier , 2021 , Article)
      Background Reinfection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been documented, raising public health concerns. SARS-CoV-2 reinfections were assessed in a cohort of antibody-positive persons ...

    • SARS-CoV-2 does not replicate in HaCaT spontaneously immortalized human keratinocytes: implications for the pathogenesis of COVID-19-associated skin manifestations 

      Zupin, Luisa; Moltrasio, Chiara; Genovese, Giovanni; Milani, Margherita; Fontana, Francesco; ... more authors ( John Libbey Eurotext , 2022 , Article)
      Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-related cutaneous manifestations have been reported [1], however, the direct or indirect role of SARS-CoV-2 infection in their pathophysiology is still debated ...

    • SARS-CoV-2 infection among primary healthcare workers: a cross- sectional study 

      Qotba, Hamda; Hamed, Ehab; Alnuaimi, Ahmed; Saad, Azza; Nasrallah, Gheyath; ... more authors ( GERMS , 2021 , Article)
      Healthcare workers (HCWs) are critical to the healthcare system and are at an increased risk of SARS-CoV-2 infection. They may acquire infections from the community and their work settings. To date, the majority of the ...

    • SARS-CoV-2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study 

      Mahmoud, Mai A.; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Hasan, Mohammad R.; ... more authors ( Wiley , 2023 , Article)
      Background: We investigated the contribution of age, coexisting medical conditions, sex, and vaccination to incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and of severe, critical, or ...

    • SARS-CoV-2 Infection and Lung Cancer: Potential Therapeutic Modalities. 

      Gupta, Ishita; Rizeq, Balsam; Elkord, Eyad; Vranic, Semir; Al Moustafa, Ala-Eddin ( MDPI , 2020 , Article Review)
      Human coronaviruses, especially SARS-CoV-2, are emerging pandemic infectious diseases with high morbidity and mortality in certain group of patients. In general, SARS-CoV-2 causes symptoms ranging from the common cold to ...

    • SARS-CoV-2 Infection and Smoking: What is the association? A brief review 

      Ishita, Gupta; Sohail, Muhammad Umar; Elzawawi, Khaled E.; Amarah, Ahmed H.; Vranic, Semir; ... more authors ( Elsevier , 2021 , Article)
      Susceptibility to severe illness from COVID-19 is anticipated to be associated with cigarette smoking as it aggravates the risk of cardiovascular and respiratory illness, including infections. This is particularly important ...

    • SARS-CoV-2 infection hospitalization, severity, criticality, and fatality rates in Qatar 

      Seedat, Shaheen; Chemaitelly, Hiam; Ayoub, Houssein H.; Makhoul, Monia; Mumtaz, Ghina R.; ... more authors ( Nature Research , 2021 , Article)
      The SARS-CoV-2 pandemic resulted in considerable morbidity and mortality as well as severe economic and societal disruptions. Despite scientific progress, true infection severity, factoring both diagnosed and undiagnosed ...

    • SARS-CoV-2 Infection Is at Herd Immunity in the Majority Segment of the Population of Qatar. 

      Al-Thani, Mohamed H; Farag, Elmoubasher; Bertollini, Roberto; Al Romaihi, Hamad Eid; Abdeen, Sami; ... more authors ( Oxford University Press , 2021 , Article)
      Qatar experienced a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic that disproportionately affected the craft and manual worker (CMW) population, who comprise 60% of the total population. This study ...

    • SARS-CoV-2 infection triggers more potent antibody-dependent cellular cytotoxicity (ADCC) responses than mRNA-, vector-, and inactivated virus-based COVID-19 vaccines 

      Zedan, Hadeel T.; Smatti, Maria K.; Al-Sadeq, Duaa W.; Al Khatib, Hebah A.; Nicolai, Eleonora; ... more authors ( Wiley , 2024 , Article)
      Neutralizing antibodies (NAbs) are elicited after infection and vaccination and have been well studied. However, their antibody-dependent cellular cytotoxicity (ADCC) functionality is still poorly characterized. Here, we ...

    • SARS-CoV-2 modulates virus receptor expression in placenta and can induce trophoblast fusion, inflammation and endothelial permeability 

      Agostinis, Chiara; Toffoli, Miriam; Spazzapan, Mariagiulia; Balduit, Andrea; Zito, Gabriella; ... more authors ( Frontiers Media , 2022 , Article)
      SARS-CoV-2 is a devastating virus that induces a range of immunopathological mechanisms including cytokine storm, apoptosis, inflammation and complement and coagulation pathway hyperactivation. However, how the infection ...

    • SARS-CoV-2 re-infection: a case report from Qatar 

      AlFehaidi, Alanoud; Ahmad, Syed Ali; Hamed, Ehab ( Elsevier , 2021 , Article)
      We read with interest the study of Gousseff et al.1 The study reported a second acute COVID-19 episode in 11 patients. A novel coronavirus (SARS-CoV-2) caused a pandemic end of 2019. Common signs of SARS-CoV-2 include ...

    • SARS-CoV-2 RNA Recovery from Air Sampled on Quartz Fiber Filters: A Matter of Sample Preservation? 

      Licen, Sabina; Zupin, Luisa; Martello, Lorenzo; Torboli, Valentina; Semeraro, Sabrina; ... more authors ( MDPI , 2022 , Report)
      The airborne route of transmission of SARS-CoV-2 was confirmed by the World Health Organization in April 2021. There is an urge to establish standardized protocols for assessing the concentration of SARS-CoV-2 RNA in air ...

    • SARS-CoV-2 seroprevalence in the urban population of Qatar: An analysis of antibody testing on a sample of 112,941 individuals 

      Peter V., Coyle; Chemaitelly, Hiam; Ben Hadj Kacem, Mohamed Ali; Abdulla Al Molawi, Naema Hassan; El Kahlout, Reham Awni; ... more authors ( Elsevier , 2021 , Article)
      The study objective was to the assess level of detectable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in the urban population of Qatar. Antibody testing was performed on residual blood specimens ...

    • SARS-CoV-2 Short-Time Infection Produces Relevant Cytopathic Effects in Vero E6 Cell Line. 

      Zupin, Luisa; Fontana, Francesco; Gratton, Rossella; Milani, Margherita; Clemente, Libera; ... more authors ( MDPI , 2021 , Article)
      Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is mainly transmitted through respiratory droplets from positive subjects to susceptible hosts or by direct contact with an infected individual. Our study ...